Wnt Signaling in Development and Disease

This volume offers a comprehensive view of how the highly conserved Wnt signaling pathway regulates development, tissue homeostasis and disease

Terry P. Yamaguchi (Volume editor), Karl Willert (Volume editor)

9780128201671, Elsevier Science

Hardback, published 23 March 2023

424 pages
22.9 x 15.1 x 2.7 cm, 0.45 kg

Wnt Signaling in Stem Cells, Development and Regeneration, Volume 153, delves into the biology of Wnt signaling in a wide variety of model organisms. Since their first identification in 1982, Wnt proteins and their downstream effectors have captivated the attention of many researchers in a variety of fields, including developmental biology, cell signaling, structural biology, stem and cancer cell biology and regeneration. Wnt signaling, along with a small number of highly conserved signaling modules including the Hedgehog, FGF, BMP, RA and Notch pathways, orchestrates morphogenesis across all metazoans. Readers will find information on recent discoveries in the Wnt field, including interactions between Wnt and other signaling pathways, and tools and technologies to interrogate the complexity of Wnt signaling.

1. The logistics of Wnt production and delivery
   Ines Alvarez-Rodrigo, David Willnow, and Jean-Paul Vincent
2. Visualizing WNT signaling in mammalian systems
   Tanne van der Wal and Ren
3. Wnt signaling and the regulation of pluripotency
   Pooja Sonavane and Karl Willert
4. Wnt signaling in stem cells during development and cell lineage specification
   Rony Chidiac and Stephane Angers
5. The role of Wnt signaling in the development of the epiblast and axial progenitors
   Ruby E. Schnirman, Samuel J. Kuo, Ryan C. Kelly, and Terry P. Yamaguchi
6. Role of Wnt signaling and planar cell polarity in left-right asymmetry
   Katsura Minegishi, Xiaorei Sai, and Hiroshi Hamada
7. Non-canonical WNT5A-ROR signaling: New perspectives on an ancient developmental pathway
   Sara E. Konopelski Snavely, Srisathya Srinivasan, Courtney A. Dreyer, Jia Tan, Kermit L. Carraway III, and Hsin-Yi Henry Ho
8. The role of Wnt signaling in Xenopus neural induction
   Ian Velloso, Wonhee Han, Xi He, and Jose G. Abreu
9. Wnt regulation of hematopoietic stem cell development and disease
   Kelsey A. Carpenter, Kate E. Thurlow, Sonya E.L. Craig, and Stephanie Grainger
10. Role of Wnt signaling in the maintenance and regeneration of the intestinal epithelium
    Maxime Gasnier, Hui Yi Grace Lim, and Nick Barker
11. Got WNTS? Insight into bone health from a WNT perspective
    Sonya E.L. Craig, Megan N. Michalski, and Bart O. Williams
12. Wnt signaling in whole-body regeneration
    Christian P. Petersen
13. From injury to patterning—MAPKs and Wnt signaling in Hydra
    Anja Tursch and Thomas W. Holstein

Subject Areas: Botany & plant sciences [PST]