White Matter Dementia

Presenting the novel concept of white matter dementia, this unique book offers hope for a better understanding and treatment of dementia.

Christopher M. Filley (Author)

9781107035416, Cambridge University Press

Hardback, published 28 April 2016

224 pages, 23 b/w illus. 28 tables
25.3 x 19.3 x 1.5 cm, 0.69 kg

'This book provides a fascinating and complete overview of the role of white matter in cognition. It provides new insights into disease and is to be recommended for neurologists and basic researchers in the field of dementia.' Jolien F. Leijenaar and Philip Scheltens, Brain

Breaking away from prevailing views of dementia that rely heavily on the role of the cerebral cortex, the new perspective put forth here highlights white matter-cognition relationships, presenting an expanded view of dementia and its neurobiological origins. Based on detailed patient observations, extensive clinical research and an exhaustive literature review, this book discusses the novel concept of white matter dementia, offering hope for better understanding and treatment of dementing illness. Covering topics such as white matter neurobiology, mild cognitive dysfunction and Alzheimer's disease, the author reconsiders brain-behavior relationships and expands the concept of dementia, discussing implications for diagnosis, treatment (medical, surgical, rehabilitative, and psychiatric) and therapeutic innovations aimed at prevention of white matter damage and restoration of myelin. This unique book is an absolute must-have for all medical specialists and consultants in neurology, neuropsychiatry, and neuropsychology involved with the growing challenge of dementia.

Preface
1. Brain-behavior relationships: a reconsideration
2. The essential contributions of neuroimaging
3. White matter neurobiology
4. A neuroanatomic overview of dementia
5. Expanding the concept of dementia
6. White matter disorders
7. White matter dementia
8. Mild cognitive dysfunction: a precursor syndrome
9. Diagnosis
10. Prognosis
11. Treatment
12. White matter and cognition: research perspectives
13. Therapeutic innovations
14. Alzheimer's disease and white matter
15. Chronic traumatic encephalopathy and white matter
16. Beyond corticocentrism
Index.

Subject Areas: Psychiatry [MMH], Neurology & clinical neurophysiology [MJN]