Somewhere west of the Appalachians and north of the Ohio River, the Midwest begins. Just where exactly, and how, and why are the questions explored in Where East Meets (Mid)West. Bringing together a range of perspectives, the volume argues that while cultural boundaries remain difficult to define, Ohio has been central to regional transitions throughout history. To Native Americans, Ohio was the meeting place of two major drainage basins: the Ohio River and the Great Lakes Basin, which resulted in large amounts of trade activity, cultural exchange, and conflict. During America's westward expansion, Ohio was an essential pathway, the first of the new Northwest territories to gain statehood, and a battleground over the issue of enslavement.