Volatile Biomarkers
Non-Invasive Diagnosis in Physiology and Medicine

A comprehensive review of the use of volatile biomarkers in exhaled breath and other bodily excretions for clinical diagnosis and therapeutic monitoring

Cristina Davis (Edited by), Jonathan Beauchamp (Edited by)

9780444626134, Elsevier Science

Hardback, published 17 May 2013

600 pages, Approx. 200 illustrations (50 in full color)
23.4 x 19 x 3.3 cm, 1.48 kg

"The book appropriately starts with a discussion of interpreting breath analyses, and readers quickly learn that the lack of standardization for specimen collection, patient preparation, or laboratory analytical methodology has greatly limited its applicability to assessing human health or disease…This book nicely summarizes the current state of the art of VOC detection and analysis for a variety of interesting applications." --Doody.com, November 2013

Volatile organic compounds (VOCs) in exhaled breath, sweat or urine carry much information on the state of human health. The role of VOCs in clinical diagnosis and therapeutic monitoring is expected to become increasingly significant due to recent advances in the field. Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine includes the latest discoveries and applications for VOCs from the world's foremost scientists and clinicians working in this emerging analytic area.

A: Interpretation of Breath Analysis Data
  1. Mathematical and Statistical Approaches for Interpreting Biomarker Compounds in Exhaled Human Breath
  2. Issues and Challenges in Human Breath Research: Perspectives from Our Experience
B: Real-Time Analysis of Exhaled Breath
  3. Physiological Modeling for Analysis of Exhaled Breath
C: Physiological and Clinical Studies
  4. Recent SIFT-MS Studies of Volatile Compounds in Physiology, Medicine and Cell Biology
  5. The Analysis of Oral Air by Selected Ion Flow Tube Mass Spectrometry Using Indole and Methylindole as Examples
  6. Smokers Breath as Seen by Proton-Transfer-Reaction Time-of-Flight Mass Spectrometry (PTR-TOF-MS)
  7. Exhaled Breath Analysis in Occupational Medicine
  8. Volatile Organic Compounds in Human Breath: Biogenic Origin and Point-of-Care Analysis
Approaches
  9. Breath Analysis in Critically Ill Patients—Potential and Limitations
  10. Analysis of Cancer Biomarkers in Exhaled Breath and Comparison with Sensory Indications by Dogs
D: Nitric Oxide, No, and Carbon Monoxide, Co
  11. Added Value with Extended NO Analysis
  12. Carbon Monoxide as an Exhaled Biomarker of Pulmonary Diseases
  13. Exhaled Nitric Oxide in Clinical Practice: Recent Advances and New Challenges
E: Clinical Breath Tests
  14. An Update on 13C-Breath Tests: The Transition to Acceptability into Clinical Practice
F: Development and Use Of Sensors
  15. Sensors for Exhaled Gas Analysis: An Analytical Review
  16. Arrays of Nanomaterial-Based Sensors for Breath Testing
  17. Smart Sensor Systems for Human Health Breath Monitoring Applications
  18. VOC Analysis by SIFT-MS, GC-MS, and Electronic Nose for Diagnosing and Monitoring Disease
G: Exhaled Breath Condensate (Ebc) And Particulates
  19. Measurement of Biomarkers of Oxidative Stress and Airway Inflammation in Exhaled Breath Condensate: Methodology and Potential Applications in Patients with COPD and Healthy Smokers
  20. Particles in Exhaled Air—A Novel Method of Sampling Non-Volatiles in Exhaled Air
H: Volatiles Of Microbial Origin: Urine, Stool and In Vitro Cultures
  21. Challenges in the Investigation of Volatile Disease Biomarkers in Urine
  22. Volatile Organic Compounds (VOCs) Found in Urine and Stool
  23. Volatile Organic Compounds (VOCs) Released by Pathogenic Microorganisms in vitro: Potential Breath Biomarkers for Early-Stage Diagnosis of Disease
I: Urban Search and Rescue Operations
  24. Potential Applications of Volatile Organic Compounds in Safety and Security

Subject Areas: Organic chemistry [PNN], Analytical chemistry [PNF], Pharmacology [MMG], Medical diagnosis [MJA]