Vascular Cognitive Impairment in Clinical Practice

Gives a broad clinical perspective on vascular cognitive impairment, and creates a foundation for the implementation of good dementia care.

Lars-Olof Wahlund (Edited by), Timo Erkinjuntti (Edited by), Serge Gauthier (Edited by)

9780521875370, Cambridge University Press

Hardback, published 12 February 2009

254 pages, 17 b/w illus. 5 colour illus. 25 tables
25.2 x 19.2 x 1.3 cm, 0.71 kg

'This is a major contribution to the field. It sorts out in clear fashion a very tangled literature. … The excellent organisation and editing of this book, its careful elaboration of complex concepts, and the practical application of this synthesis give rise to a first-rate work. This much-needed book deserves a wide readership.' David O. Staats MD, University of Oklahoma Health Sciences Center

Vascular cognitive impairment is the second most common cause of dementia after Alzheimer's disease and is expected to grow in prevalence with the aging global population. The purpose of this authoritative book is to give a broad clinical perspective on vascular cognitive impairment and thus create a foundation for the implementation of good dementia care. The book focuses on pathophysiology, diagnosis, treatment and prevention. It demonstrates the underlying causes of the disorder, such as the manner in which vascular risk-factors influence the onset of vascular cognitive impairment. The concept of mixed forms of vascular dementia, Alzheimer's dementia and other vascular diseases is discussed as well as the influence of vascular changes with regard to the onset of Alzheimer's disease. The detailed section on pathophysiology will enhance clinicians' understanding of this complex disorder. Finally there is a section on pharmacological and neuropsychological treatment of cognitive and psychiatric symptoms.

List of contributors
Preface
Part I. Diagnosis: 1. Diagnosing vascular cognitive impairment and dementia – concepts and controversies Timo Erkinjuntti and Serge Gauthier
2. Vascular cognitive impairment - prodrome to VaD? Adriane Mayda and Charles DeCarli
3. Clinical evaluation: a systematic but user-friendly approach Oscar L. Lopez and David A. Wolk
4. Cognitive functioning in vascular dementia before and after diagnosis Erika J. Laukka, Sari Karlsson, Stuart W. S. MacDonald and Lars Bäckman
5. Structural neuroimaging: CT and MRI Wiesje M. van der Flier, Salka S. Staekenborg, Frederik Barkhof and Philip Scheltens
6. Functional imaging in vascular dementia – clinical practice Lars-Olof Wahlund and Rimma Axelsson
7. Biomarkers in vascular dementia Anders Wallin and Tuula Pirttilä
Part II. Pathophysiology: 8. Physio-pathology of large vessel vascular dementia Leonardo Pantoni, Francesca Pescini and Anna Poggesi
9. Small vessel diseases of the brain Raj N. Kalaria and Timo Erkinjuntti
10. White matter changes Franz Fazekas, Christian Enzinger, Stefan Ropele and Reinhold Schmidt
11. Hereditary forms of cerebrovascular amyloidosis Agueda Rostagno and Jorge Ghiso
12. Role of vascular risk factors in dementia Chengxuan Qiu and Laura Fratiglioni
13. Cardiovascular disease, cognitive decline, and dementia Angela L. Jefferson and Emelia J. Benjamin
14. Vascular factors in Alzheimer's disease: from diagnostic dichotomy to integrative etiology Miia Kivipelto, Alina Solomon and Tiia Ngandu
Part III. Treatment: 15. Treatment of cognitive changes Serge Gauthier and Timo Erkinjuntti
16. Treatment of functional decline Lena Borell
17. Treatment of behavioral symptoms in vascular dementia Catherine Cole and Alistair Burns
18. Control of vascular risk factors Deborah Gustafson and Ingmar Skoog
Index.

Subject Areas: Psychiatry [MMH], Geriatric medicine [MJX], Neurology & clinical neurophysiology [MJN]