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Twin and Family Studies of Epigenetics
Provides expert guidance in epigenetic twin and family study design, research methods, areas of application, recent findings, and future directions
Shuai Li (Edited by), John Hopper (Edited by), Trygve O Tollefsbol (Series edited by)
9780128209516, Elsevier Science
Paperback, published 20 August 2021
374 pages, 70 illustrations (30 in full color)
23.5 x 19 x 2.4 cm, 0.75 kg
Twin and Family Studies of Epigenetics, Volume 27, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more. Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects.
ART 1 Introduction 1. Value of twin and family study designs for epigenetic research 2. Evaluation and measurement of epigenetic modifications in population-based studies PART 2 Human health applications 3. Discordant monozygotic twin studies of epigenetic mechanisms in mental health 4. DNA methylation and breast cancer risk: value of twin and family studies 5. Twin and family studies on epigenetics and oral health 6. Twin and family epigenetic studies of type 2 diabetes 7. Twin and family studies on epigenetics and obesity 8. DNA methylation and blood pressure in Chinese adult twins 9. Twin and family studies on epigenetics of autoimmune diseases 10. Twin studies on the epigenetics of selected neurological disorders and carotid artery disease 11. Disease-discordant twin studies of epigenetics and cancer 12. Sex differences in epigenetic profiles: The value of twin studies PART 3 Emerging approach 13. Combining twin-family designs with measured genetic variants to study the causes of epigenetic variation 14. Imaging epigenetics and the radiogenomics 15. DNA methylation changes specific to environmental exposures: The strengths of twin studies using cigarette smoking as an example 16. Time trends in epigenetic signatures and population health risks 17. Ambient air pollution and human epigenetic modifications
Subject Areas: DNA & Genome [PSAK1], Genetics [non-medical PSAK]
