Twentieth Century Mouse Genetics
A Historical and Scientific Review

Presents key advances in mouse genetic models throughout the 20th century and their applicability to modern research and medicine

Robert P. Erickson (Author)

9780128240168, Elsevier Science

Paperback, published 6 September 2021

344 pages, 40 illustrations
23.5 x 19 x 2.2 cm, 0.63 kg

"This book will have strong appeal to a limited audience. Those interested in the history and development of mouse genetics, and of mouse genetics in the wider context of the history of genetics, will find this book an interesting read. Indeed, it stands out from other books covering similar topics by the personal experience of the author in the field. " --© Doody’s Review Service, 2021, Mark F. Sanders, PhD, reviewer, expert opinion

Twentieth Century Mouse Genetics: A Historical and Scientific Review provides a comprehensive examination of key advances in mouse genetics throughout the 20th century. Here Dr. Robert P. Erickson, a leader in the field, identifies the contributions of historic mouse genetics studies, and how those approaches and early discoveries are still shaping human genetics research and medical genetics today. In addition to historical overviews, the author provides researcher biographies and updates connecting historic research to ongoing advances. Past studies discussed use the T/t complex as an example and include the origins of mouse genetics, the synthesis of genetics and evolution, cytogenetics and gene mapping, population genetics and mutation research, immunogenetics, reproductive genetics, molecular cloning, X-inactivation and epigenetics, sex determination, and pharmacogenetics. Here researchers, students, and clinicians will find fresh inspiration to engage in human genetics research employing mouse models and to translate those findings to clinical practice.

1. The origins of mouse genetics and the discovery of the T-locus
2. The evolutionary modern synthesis, t-haplotypes in the wild, and reproductive isolation
3. Linkage studies, cytogenetics, and the discovery that t-haplotypes consist of a series of inversions—an over-the-Century Project
4. Developmental genetics and recessive t-lethals
5. More population genetics with particular attention to the effects of t-allele mediated transmission ratio distortion
6. Mutation studies including those targeting the T/t-complex—a century long project
7. Immunogenetics and the failed search for t-antigens–from mid-century and continuing to it’s end
8. Gametogenesis and the genetics of gametes, including t-haplotype segregation distortion
9. The cloning era and the cloning of Brachury and other T/t complex genes
10. X-inactivation, epigenetics, and imprinting, including of the T/t complex
11. Sex determination, sex differentiation, and the Y chromosome—a mostly last quarter of the century effort
12. Pharmacogenetics—a mostly last half of the century effort
Book Bibliography

Subject Areas: Molecular biology [PSD], DNA & Genome [PSAK1], Genetics [non-medical PSAK]