Transporters in Drug Discovery and Development
Detailed Concepts and Best Practice

A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development, with balanced coverage of molecular biology aspects and functional outcomes

Yurong Lai (Author)

9781907568213, Elsevier Science

Hardback, published 31 October 2013

780 pages
23.3 x 15.6 x 4 cm, 1.23 kg

Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments.

Membrane transporters and the diseases corresponding to functional defects
P-glycoprotein (P-gp/MDR1)/ABCB1
Multidrug resistance- associated protein 2 (MRP2/ABCC2)
Breast cancer resistance protein (BCRP)/ABCG2
The bile salt export pump (BSEP/ABCB11)
Organic anion- transporting polypeptides (OATPs/SLCOs)
Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs)
Drug transporters in drug discovery and development
Transporter study methodologies.

Subject Areas: Biochemistry [PSB], Pharmacology [MMG]