Transport of Molecules across Microbial Membranes

An up-to-date review of an important area in microbiology.

J. K. Broome-Smith (Edited by), S. Baumberg (Edited by), C. J. Stirling (Edited by), F. B. Ward (Edited by)

9780521772709, Cambridge University Press

Hardback, published 14 October 1999

288 pages, 47 b/w illus. 1 colour illus. 12 tables
23.6 x 15.8 x 2.2 cm, 0.6 kg

"...well written and provides a review on the latest research in the area, with extensive references abailable to the reader. The tables and figures presented in Transport of Molecules Across Microbial Membranes could be valuable learning tools for students and instructors." Canadian Society of Microbiologists

This volume considers the transport of molecules, large and small, across the membranes of prokaryotic and eukaryotic microbial cells. A diverse range of related phenomena are covered, but the unifying themes are the signal peptides that target proteins to particular destinations, and the role of chaperonins. Topics covered include: secretion of proteins out of the bacterial cell by Type I, II and III mechanisms, including the newly recognised bacterial signal recognition pathway in Type II; passage across internal membranes of eukaryotic proteins, whether destined for secretion or en route to internal organelles such as chloroplasts and peroxisomes; how bacteria obtain the energy required for solute uptake, the role of phosphorylation, and evolutionary relationships of some of the proteins involved; and efflux pumps for toxic substances in bacterial, animal and plant cells.

Preface
1. Overview: transport of molecules across microbial membranes - a sticky business to get to grips with J. K. Broome-Smith and C. Mitsopoulos
2. Multidrug resistance efflux K. Lewis
3. Regulation of solute accumulation in bacteria and its physiological significance B. Poolman
4. Arsenic transport systems from Escherichia coli to humans H. Bhattacharjee, M. Ghosh, R. Mukhopadhyay and B. P. Rosen
5. Type II protein secretion: the main terminal branch of the general secretory pathway A. Filloux
6. Type III secretion and the pathogenesis of Yersinia infections D. M. Anderson, L. W. Cheng, V. T. Lee, S. Masmanian, K. Ramamurthi, C. Tam and O. Schneewind
7. Assembly of bacterial adhesins across the outer membrane via the chaperone-usher pathway G. E. Soto and S. J. Hultgren
8. DNA uptake by transformable bacteria S. A. Lacks
9. Escherichia coli signal recognition particle - a historical perspective Q. A. Valent, E. N. S. O'Gorman, P. Scotti, J. Luirink and S. High
10. Protein translocation into the endoplasmic reticulum B. P. Young, J. K. Brownsword and C. J. Stirling
11. Peroxisome biogenesis E. Lopez-Huertas and A. Baker
12. Transport of proteins into and across the thylakoid membrane C. Robinson, W. Edwards, P. J. Hynds and C. Tissier
13. Evolutionary origins of transmembrane transport systems M. H. Saier Jr and T.-T. Tseng
Index.

Subject Areas: Microbiology [non-medical PSG]