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Translational Research and Discovery in Gastroenterology
Organogenesis to Disease
Deborah L. Gumucio (Author), Linda C. Samuelson (Author), Jason R. Spence (Author)
9781118492871, Wiley
Hardback, published 25 July 2014
352 pages
25.2 x 17.8 x 2.3 cm, 0.898 kg
Translational Gastroenterology: Organogenesis to Disease bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of research, with chapters devoted to recent advances in the field of GI stem cell biology, and the potential for tissue engineering of GI organs. The topics covered provide a unique window onto current activity in the field of gastroenterology, fostering enhanced knowledge for developmental biologists as well as for clinical practitioners. Notable features include the following: • Basic science chapters review the molecular and cellular pathways of GI organ development alongside clinical chapters examining organ-based diseases, closing the gap between the bench and the clinic. • Derivative organs – esophagus, stomach, pylorus, small intestine, colon, liver, and pancreas –as well as tissues such as serosa and enteric nervous system that are common to multiple GI organs. • Chapters detailing the use of model organisms – Drosophila, sea urchin, zebrafish, C. elegans, Xenopus – for basic discovery studies are included. • Chapters on GI stem cells and the potential for tissue engineering of the GI organs provide a view to the future of research and therapy in these organs.
List of Contributors ix Foreword xiii Preface xv 1 Endoderm Development: From Progenitors to Organ Buds 1 2 Genetic and Cellular Mechanisms Regulating Esophageal Development 15 3 Congenital and Acquired Diseases of the Esophagus 27 4 Basic Science of Stomach Development 43 5 Congenital and Acquired Diseases of the Stomach 57 6 The Pylorus: Development and Disease 73 7 Basic Science of Small Intestinal Development 85 8 Clinical Small Intestine 99 9 Basic Science of Colon Development 113 10 Congenital and Acquired Diseases of the Colon 125 11 Intestinal Serosa 139 12 Basic Science of Liver Development 151 13 Congenital and Acquired Diseases of the Liver 165 14 Developmental Biology of the Pancreas 179 15 Congenital Disorders of the Pancreas 193 16 Enteric Nervous System Development 209 17 Congenital and Acquired Disorders of the Enteric Nervous System 225 18 Gut Development in the Sea Urchin 241 19 Intestinal Stem Cell Specification in the Drosophila Midgut 253 20 The Caenorhabditis elegans Intestine 263 21 Xenopus as a Model for GI Development 275 22 Zebrafish Models of GI Development and Disease 289 23 Gastrointestinal Stem Cells 303 24 Translating Embryonic Development into Models of Human Gastrointestinal Development and Disease 317 Index 327
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Subject Areas: Biology, life sciences [PS]
