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Translational Immunology
Mechanisms and Pharmacologic Approaches

A comprehensive overview of the mechanisms underlying emerging pharmacologic approaches to interventional immunology

Seng-Lai Tan (Author)

9780128015773

Hardback, published 8 December 2015

384 pages
23.4 x 19 x 2.6 cm, 1.02 kg

Translational Immunology: Mechanisms and Pharmacologic Approaches highlights and summarizes the most important advances in human immunology, clinical translations, new tools to analyze therapeutic targets, and new pharmacological approaches for autoimmunity, inflammatory disorders, and cancer. The book is an essential resource for those seeking to understand the potential translational applications of burgeoning studies in human immunology, helping readers make sense of the existing and emerging scientific advances. The book grounds fundamental science in the translational realm, providing insights from world renowned researchers at the top of their game in their respective fields, in both industry and academic settings.

Readers will gain an understanding of the rationale and mechanisms underlying current and emerging pharmacologic approaches for interventional immunology, the gaps therein, and new ideas for better and safer therapeutic approaches, and physicians will glean information about pharmacological limitations in altering disease progression and complications. This reference on the translational realization of the burgeoning findings in immunology provides a go-to reference for experienced professional clinicians, researchers, industry scientists, and those seeking more information on the field.

Preface Section A: Human Immunology1. Systems Immunology2. Primary Immunodeficiencies3. Phenome-wide association study (PheWAS)4. Gene Regulatory Network5. TCR Repertoire Analysis Section B: Current and Emerging Pharmacological Targets6. TH177. TH98. TFH9. Regulatory T cells10. Regulatory B cells Section C: New Approaches11. Immune Tolerance Induction12. Humanized Mouse Models 13. Patient Stratification and Biomarkers

Subject Areas: Pharmacology [MMG], Immunology [MJCM]

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