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Translational Endocrinology of Bone
Reproduction, Metabolism, and the Central Nervous System
First translational reference to focus on bone as an endocrine organ system, from appetite, to metabolism and growth, to reproduction
Gerard Karsenty (Edited by)
9780124157842, Elsevier Science
Hardback, published 19 December 2012
236 pages
27.6 x 21.5 x 2.1 cm, 0.94 kg
"This is a valuable contribution to the field of bone biology. It is a must read for all researchers in the field of bone pathology. It is also a good book for physicians caring for patients with bone disorders as it provides a review of bone pathology in the context of other body systems." Rating: 4 Stars --Doody.com, May 2, 2014 "…17 articles…discuss the effects of bone on whole-organism physiology and how the study of this discipline aids in the understanding of the pathogenesis of degenerative diseases affecting several organs. Chapters address various hormones and neuromediators ranging from serotonin to osteocalcin, as well as knowledge about the ability of bone to regulate phosphate metabolism." --ProtoView.com, March 2014
The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. This is the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertility. This book is a timely reference for both basic and clinical researchers in bone biology and endocrinology.
1. Introduction
2. Bone Remodelling & Regulation*
3. Food Intake of Bone Formation
4. Central Control of Bone Mass
5. Neuropeptide Y and Bone Formation
6. Serotonin: The Central Link between Bone Mass and Energy Metabolism
6. Gut Serotonin Bone Formation
7. Gut Serotonin and Osteoporosis
8. Regulation of Bone Resoprtion by PPARGamma
10. Regulation of Energy Metabolism by Bone
11. Bone Marrow Fat and Bone Mass
12. Bone Mass and Energy Metabolism in Humans
13. Regulation of Fertility by Bone
14. Molecular Signaling by Osteocalcin
15. Regulation of Phosphate Metabolism by FGF23
16. The Clinical Use of FGF 23
17. Transcriptional Regulation of the Endocrine Function of Bone
