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Transgenerational Epigenetics
Examines the inheritance of epigenetic phenomena between generations, with an emphasis on disease relevance, drug discovery, and next steps in clinical translation
Trygve O Tollefsbol (Volume editor)
9780128163634
Paperback, published 21 May 2019
518 pages
23.4 x 19 x 3.2 cm, 1.09 kg
Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born. This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as are current debates and future directions for research.
1. Generational epigenetic inheritance SECTION I Definitions and history of generational epigenetic inheritance 2. Definition of epigenetic transgenerational inheritance and biological impacts 3. Historical perspective of transgenerational epigenetics SECTION II Germline epigenetics 4. Epigenetic changes in the mammalian paternal germ line SECTION III Parental epigenetic inheritance 5. Maternal epigenetic inheritance 6. Paternal epigenetic inheritance SECTION IV Basic mechanisms/processes of epigenetic inheritance 7. Towards the molecular mechanisms of transgenerational epigenetic inheritance: insights from transgenic mice 8. Histone-mediated transgenerational epigenetics 9. Heritable generational epigenetic effects through small noncoding RNA 10. Long noncoding RNA and epigenetic inheritance SECTION V Model organisms 11. Nonmammalian model organisms in epigenetic research:an overview 12. Plant models of transgenerational epigenetic inheritance 13. Epigenetics and heritable phenotypic variations in livestock 14. Transgenerational epigenetic inheritance in insects SECTION VI Evolution of transgenerational epigenetics 15. Evolutionary perspectives on transgenerational epigenetics 16. Inheritance of epigenome variants across generations during evolution SECTION VII Environmental epigenetic effects on the offspring 17. Transgenerational epigenetics of endocrine-disrupting chemicals in mammals 18. Transgenerational effects of imprinting 19. Epigenetic inheritance across multiple generations SECTION VIII Impact of transgenerational epigenetics on disease 20. Transgenerational epigenetics, paternal obesity, and insulin resistance 21. Epigenetic inheritance of type 2 diabetes SECTION IX Clinical significance of transgenerational epigenetics 22. Clinical aspects of transgenerational epigenetics
Subject Areas: DNA & Genome [PSAK1], Genetics [non-medical PSAK]
