Trafficking of GPCRs

GPRC trafficking experts review recent important findings in the field, including exocytosis and endocytosis

Guangyu Wu (Author)

9780128029398, Elsevier Science

Hardback, published 2 June 2015

328 pages
22.9 x 15.1 x 2.4 cm, 0.66 kg

G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface receptors that regulate a variety of cell functions. Over the past few decades great progress has been made in defining the roles of intracellular trafficking in controlling the functionality of the receptors as well as in the development of various human diseases. This volume of Progress in Molecular Biology and Translational Science reviews the recent understanding of GPCR trafficking regulators and molecular mechanisms.

1. Arrestins: Critical Players in Trafficking of Many GPCRsVsevolod V. Gurevich and Eugenia V. Gurevich
2. Regulation of GPCR Trafficking by UbiquitinJustine E. Kennedy and Adriano Marchese
3. Rhodopsin Trafficking and Mistrafficking: Signals, Molecular Components and MechanismsIna Nemet, Philip Ropelewski and Yoshikazu Imanishi
4. Intracellular Trafficking of Neuropeptide Y ReceptorsKarin Mörl and Annette G. Beck-Sickinger
5. Insights into Serotonin Receptor Trafficking: Cell Membrane Targeting and InternalizationMichèle Darmon, Sana Al Awabdh , Michel-Boris Emerit and Justine Masson
6. Calcium-Sensing Receptor: Trafficking, Endocytosis, Recycling and Importance of Interacting ProteinsKausik Ray
7. Trafficking of ß Adrenergic Receptors: Implications in Intracellular Receptor SignalingQin Fu and Yang K. Xiang
8. Post-endocytic sorting of Adrenergic and Opioid Receptors: New Mechanisms and Functions.Shanna L. Bowman and Manojkumar A. Puthenveedu
9. a2 Adrenergic Receptor Trafficking as a Therapeutic Target in Antidepressant Drug ActionChristopher Cottingham, Craig J. Ferryman and Qin Wang
10. Regulation of a2B-Adrenerigc Receptor Export Trafficking by Specific Motifs Guangyu Wu, Jason E. Davis and Maoxiang Zhang
11. Temperature-Sensitive Intracellular Traffic of ?2c-Adrenergic ReceptorCatalin M. Filipeanu
12. N-Terminal Signal Peptides of G Protein-Coupled Receptors: Significance for Receptor Biosynthesis, Trafficking and Signal TransductionClaudia Rutz, Wolfgang Klein and Ralf Schülein
13. Regulation of GPCR Anterograde Trafficking by Molecular Chaperones and Motifs Brent Young, Jaime Wertman and Denis J. Dupré

Subject Areas: Molecular biology [PSD], Biochemistry [PSB], Biophysics [PHVN]