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Toxicological Risk Assessment and Multi-System Health Impacts from Exposure
A comprehensive multidisciplinary reference on contemporary issues and key topics in modern toxicology
Aristidis M. Tsatsakis (Edited by)
9780323852159, Elsevier Science
Paperback / softback, published 5 August 2021
684 pages, 250 illustrations (50 in full color)
23.5 x 19 x 4.2 cm, 1.83 kg
Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment.
Part 1: Modern tools and concepts in toxicology testing 1. Mixture toxicity evaluation in modern toxicology 2. Alternative methods and their role in modern toxicology 3. The exposome—a new paradigm for nonanimal toxicology and integrated risk assessment 4. In silico toxicology, a robust approach for decision-making in the context of next-generation risk assessment 5. Safety science in the 21st century—a scientific revolution in its making 6. Chemobrain Part 2: Methods and toxicity models in toxicology 7. "Predictive in silico toxicology." An update on modern approaches and a critical analysis of its strong and weak points 8. Analytical strategies to study the gut microbiome in toxicology 9. Behavioral endpoints in adult and developmental neurotoxicity: the case of organophosphate pesticides 10. Nuclear factor erythroid 2-related factor 2-mediated antioxidant response as an indicator of oxidative stress 11. The potential of complex in vitro models in pharmaceutical toxicology Part 3: New insights in risk assessment 12. Health-based exposure limits and toxicology in pharmaceutical industry 13. The hormetic dose response: implications for risk assessment 14. Endocrine disruption and human health risk assessment in light of real-life risk simulation 15. Toxicity data as the basis for acute and short-term emergency exposure guidance 16. Renal mitochondria as sentinels for exposures to environmental toxicants and nephrotoxic drugs Part 4: Clinical biomarkers updates 17. Updates on current biomarkers in toxicology 18. The role of extracellular matrix in allergic contact dermatitis pathogenesis 19. Review of current neurotoxicology issues 20. Modern aspects of immunotoxicology 21. Toxicology of neurodegenerative diseases 22. Toxicogenetics—Pharmacogenetics: genetic variability profiling for xenobiotic response heterogeneity 23. Current and emerging concepts of cardiotoxicity 24. Metabolomics: diagnostic and therapeutic applications in clinical medicine and pharmacology 25. Metabolomics methodology and workflow: challenges and future prospects 26. Telomere length: associations with nutrients and xenobiotics Part 5: Epidemiology and public health toxicology issues 27. Dismissing the use of P-values and statistical significance testing in scientific research: new methodological perspectives in toxicology and risk assessment 28. Modern approaches for the assessment of human exposure to dietary mycotoxins 29. Tobacco toxicity and regulatory science 30. Dethroning the crown. From the kinetics and dynamics of COVID-19 diagnosis to the promising treatments 31. Toxicology issues related to COVID-19 outbreak 32. Risk assessment for heat stress during work and leisure Part 6: Pharmaceuticals and nutraceuticals toxicology updates 33. Polyphenols: the hallmark of endothelial dysfunction combatants 34. Effect of diet, pharmaceuticals, and environmental toxicants on gut microbiota imbalance and increased intestinal membrane permeability 35. Hydrogen sulfide: a shifting paradigm 36. Redox biomarkers in toxicology and nutrition: the social link 37. Safety profile of plants and phytoconstituents used in traditional medicine worldwide Part 7: Toxicology of biomaterials and nanomaterials 38. Epigenetic mechanisms in nanomaterial toxicity 39. Predictive nanotoxicology: from nanotoxicity to nanosafety of select and commonly used nanomaterials 40. The toxicological effects of titanium dioxide nanoparticles on marine microalgae 41. Aquatic nanotoxicology: reference species and omics technologies Part 8: Special topics in toxicology 42. Toxicity of arsenicals in diseases: friend or foe? 43. Toxicity of psychedelic drugs 44. Immunotoxicity of pesticides: current knowledge and perspectives 45. Glyphosate-based herbicides: evidence of immune-endocrine alteration 46. Ciguatera toxins: toxicity and food safety 47. Cannabinoids and psychosis: current challenges of mechanistic toxicology 48. Electronic cigarettes as a harm reduction concept for public health
Subject Areas: Medical toxicology [MMGT]
