Toxicogenomics-Based Cellular Models
Alternatives to Animal Testing for Safety Assessment

An authoritative resource based on real examples and current research for the application of toxicogenomics to developing alternatives to animal toxicity tests

Jos Kleinjans (Edited by)

9780123978622

Hardback, published 7 March 2014

362 pages, 25 illustrations
23.4 x 19 x 2.5 cm, 0.91 kg

"Researchers in genetics, toxicology, and other medical and public health specialties describe the current progress in developing toxicogenomics-based cellular models for chemical-induced carcinogenicity, immunotoxicity, and reproductive toxicity, all important endpoint of toxicity, the evaluation of which now costs large numbers of animal lives." --ProtoView.com, April 2014

Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well as opportunities and challenges for the future. Written by renowned international toxicological experts, this book explores ‘omics technology for developing new assays for toxicity testing and safety assessment and provides the reader with a focused examination of alternative means to animal testing.

Chapter 1. Introduction and Scoping Chapter 2. Genotoxicity and Carcinogenesis Chapter 3. Immunotoxicity Chapter 4. Reproduction Toxicity Chapter 5. Organ Toxicity Chapter 6. Toxicoinformatics Chapter 7. Validating Toxicogenomics Assays Chapter 8. Implementation Outlook

Subject Areas: Cellular biology [cytology PSF], Medical toxicology [MMGT], Pharmacology [MMG], Medical research [MBGR]