Toxicoepigenetics
Core Principles and Applications

A clear introduction to the fundamental principles and practices that are critical for an understanding of the role of the epigenome in toxicology

Shaun D. McCullough (Edited by), Dana Dolinoy (Edited by)

9780128124338, Elsevier Science

Paperback, published 7 November 2018

428 pages
23.4 x 19 x 2.7 cm, 0.86 kg

Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects of toxicology such as the role of the environment and lifestyle influencing the individual susceptibility to these effects and the trans-generational transmission of these health effects and susceptibilities. Methods chapters are included to help improve efficacy and efficiency of protocols in both the laboratory and the classroom. Toxicoepigenetics: Core Principles and Applications is an essential book for researchers and academics using epigenetics in toxicology research and study.

1. The Role of Histone Acetylation and Acetyltransferases in Gene Regulation 2. The Role of Histone Methylation and Methyltransferases in Gene Regulation 3. Linking Chromatin Accessibility with Exposure Effects and Susceptibility 4. Implications for Chromatin Biology in Toxicology 5. The Role of DNA Methylation in Gene Regulation 6. Implications of DNA Methylation in Toxicology 7. DNA Methylation as a Biomarker in Environmental Epidemiology 8. DNA Hydroxymethylation: Implications for Toxicology and Epigenetic Epidemiology 9. The Role of Non-Coding RNAs in Gene Regulation 10. miRNAs and lncRNAs as Biomarkers of Toxicant Exposure 11. Germline and Trans-generational Impacts of Toxicant Exposures 12. Novel Bioinformatics Methods for Toxicoepigenetics 13. Incorporating Epigenetics into Risk Assessment Frameworks 14. Chromatin Immunoprecipitation: General Protocol and Considerations for Analysis 15. Methods for Analysis of DNA Methylation 16. Methods for Analyzing miRNA Expression

Subject Areas: Medical toxicology [MMGT]