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Therapeutic Strategies to Overcome ALK Resistance in Cancer
Valuable information on how to treat patients with an ALK positive lung cancer, myofibroblastic cancer, lymphoma or neuroblastoma
Luc Friboulet (Edited by)
9780128217740, Elsevier Science
Hardback, published 14 January 2021
216 pages, Approx. 100 illustrations (100 in full color)
23.4 x 19 x 2 cm, 0.63 kg
"This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment." --Anticancer Research
Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field. This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment.
1. Structure and function of ALK2. ALK rearranged lung cancer: Treatment and outcome3. Systemic treatments other than TKI: reflections on chemotherapy, immunotherapy and antiangiogenic agents in ALK-driven NSCLC4. Management of ALK positive patients with tumors other than lung cancer (ALCL, neuroblastoma, Inflammatory Myofibroblastic Tumor)5. Resistance mechanisms to ALK TKIs in lung cancer: from single to compound mutations, from tissue to liquid biopsy6. Resistance mechanisms to ALK TKI in tumors other than lung cancer7. Therapeutic strategies to overcome ALK resistance in lung cancer8. Novel Therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL: use of ACD9. Drug combinations to enhance ALK TKI anti-tumor efficacy in Neuroblastoma10. State of the art and future perspectives
Subject Areas: Life sciences: general issues [PSA]
