Theoretical Biology of the Cell
A Dynamical-Systems Perspective

Using mathematical methods, this book examines life dynamics such as cellular processes, adaptation, morphogenesis, and the origin of life.

Hiroaki Takagi (Author), Chikara Furusawa (Author), Satoshi Sawai (Author), Kunihiko Kaneko (Author)

9781009397841, Cambridge University Press

Paperback / softback, published 19 June 2025

326 pages
24.3 x 16.8 x 1.7 cm, 0.57 kg

'The explosion of quantitative biology creates novel pedagogical challenges. Takagi et al. have delivered an exciting textbook covering standard topics in dynamical systems theory such as feedback loops in cell systems, but also more advanced topics, such as pattern formation, number fluctuations of biomolecules, and even the origin of life and the role of information in biology. This book is unique in its ability to inspire, as well as in its depth and clarity. I would enjoy teaching and learning from it and so will you!' Nigel Goldenfeld, University of California San Diego

To understand life phenomena, we must consider form, structure, organization, motion, and the roles they play in “living” functions. This book explores such elements through mathematical methods. Beginning with an overview of dynamical systems and stochastic processes, the chapters that follow build on experimental advances in quantitative data in cellular processes to demonstrate the applications of these mathematical methods to characterize living organisms. The topics covered include not only cellular motions but also temporal changes in metabolic components, protein levels, membrane potentials, cell types, and multicellular patterns, which are linked to functions such as cellular responses, adaptation, and morphogenesis. This book is intended for undergraduates, graduates, and researchers interested in theory and modeling in biology, in particular cell, developmental, and systems biology, also those in the fields of mathematics and physics who are interested in these topics.

1. Introduction to dynamical systems for biology
2. Input-output relationships of cell systems
3. Oscillation and excitability in cellular dynamics
4. Spatio-temporal pattern formation
5. 'fluctuation' of intracellular dynamics
6. Langevin equation and Fokker-Planck equation
7. Dynamical system model of cell differentiation
8. Spatiotemporal pattern produced by cells
9. Theoretical approaches concerning the origin of life
10. Information and biology
Notes
Index.

Subject Areas: Biophysics [PHVN]