The Value of BCG and TNF in Autoimmunity

Updated and expanded exploration of tumor necrosis factor induction and bacillus Calmette-Guérin vaccine as potential treatments for autoimmune diseases

Denise Faustman (Edited by)

9780128146033, Elsevier Science

Paperback, published 19 July 2018

200 pages
22.9 x 15.1 x 1.4 cm, 0.34 kg

The Value of BCG and TNF in Autoimmune Diseases, Second Edition provides an overview on the current research related to TNF induction and the use of the BCG vaccine as a potential treatment approach to diverse forms of autoimmunity, allergies, infections and neurologic diseases. Since the initial conference (2013) and first edition of this book (2014), the field of BCG research has grown considerably. This new edition contains updates on MS and diabetes, and features at least eight additional chapters on new prevention and treatment trials in autoimmunity and allergy, along with a new understanding of the genetics of BCGs.

1. BCG: Its Impact on Tuberculosis and Relevance to Autoimmune Disease 2. The Potential of TNF Induction from BCG for the Treatment of Type 1 Diabetes 3. Bacille Calmette-Guérin (BCG) Vaccine in Neuroinflammation 4. Host Epigenetic Modifications in Mycobacterium Tuberculosis Infection: A Boon or Bane 5. Mycobacterium Bovis Bacille Calmette-Guerin Vaccination: Can Biomarkers Predict Efficacy 6. The Heterologous Effects of Bacillus Calmette-Guérin (BCG) Vaccine and Trained Innate Immunity 7. BCG in Neonatals 8. Epigenetic Rewiring of Monocytes in BCG Vaccination 9. Mycobacteria, Immunoregulation and Autoimmunity 10. mTORC1 Links Cellular Metabolism and Immune Functions in Mycobacterium Tuberculosis Infection and BCG Vaccination 11. The Role of Maternal Priming and Boosting for the Non-Specific Effects of BCG Vaccine

Subject Areas: Immunology [MJCM]