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The Protective Arm of the Renin Angiotensin System (RAS)
Functional Aspects and Therapeutic Implications
A first of its kind reference to comprehensively describe the newly discovered protective side of the Renin Angiotensin System (RAS)
Thomas Unger (Edited by), U. Muscha Steckelings (Edited by), Robson Augusto Souza dos Santos (Edited by)
9780128013649
Paperback / softback, published 23 April 2015
316 pages
27.6 x 21.5 x 2.1 cm, 0.86 kg
The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications.
Part I: The AT2 Receptor Introduction The AT2 receptor: from enigma to therapeutic target AT2 receptor detection by selective ligands Basic mechanisms and signaling Animal models with a genetic alteration of AT2 expression AT2 signaling: resolved and unresolved AT1-AT2 crosstalk (Patho)-physiological effects of AT2R stimulation AT2R in Myocardial infarction and congestive heart failure AT2R, vascular effects, blood pressure effects AT2R in neuroprotection and -regeneration AT2R and cognitive function AT2R in kidney disease AT2R and natriuresis AT2R and vascular remodeling AT2R and inflammation AT2R, ATIP and cancer AT2R and sympathetic outflow Metabolic effects of AT2R stimulation Gender differences in AT2R expression and actions Future clinical application Discovery of non-peptide selective AT2R agonists Synthesis of peptide AT2 agonists Potential future clinical indications for AT2-agonists Part II: MAS Receptor / Ang(1-7) / ACE-2: Introduction The Mas Story Basic mechanisms and signaling Animal models with a genetic alteration of ACE2/MAS MAS signaling: resolved and unresolved MAS dimerisation and MAS/AT2 crosstalk Basic aspects of ACE-2 regulation and function (Patho)-physiological effects of MAS stimulation MAS in Myocardial infarction and congestive heart failure MAS, vascular effects, blood pressure effects MAS in neuroprotection and -regeneration MAS and cognitive function MAS in the kidney
