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The Protective Arm of the Renin Angiotensin System (RAS)
Functional Aspects and Therapeutic Implications
A first of its kind reference to comprehensively describe the newly discovered protective side of the Renin Angiotensin System (RAS)
Thomas Unger (Edited by), U. Muscha Steckelings (Edited by), Robson Augusto Souza dos Santos (Edited by)
9780128013649
Paperback / softback, published 23 April 2015
316 pages
27.6 x 21.5 x 2.1 cm, 0.86 kg
The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications.
Part I: The AT2 Receptor
Introduction
The AT2 receptor: from enigma to therapeutic target
AT2 receptor detection by selective ligands
Basic mechanisms and signaling
Animal models with a genetic alteration of AT2 expression
AT2 signaling: resolved and unresolved
AT1-AT2 crosstalk
(Patho)-physiological effects of AT2R stimulation
AT2R in Myocardial infarction and congestive heart failure
AT2R, vascular effects, blood pressure effects
AT2R in neuroprotection and -regeneration
AT2R and cognitive function
AT2R in kidney disease
AT2R and natriuresis
AT2R and vascular remodeling
AT2R and inflammation
AT2R, ATIP and cancer
AT2R and sympathetic outflow
Metabolic effects of AT2R stimulation
Gender differences in AT2R expression and actions
Future clinical application
Discovery of non-peptide selective AT2R agonists
Synthesis of peptide AT2 agonists
Potential future clinical indications for AT2-agonists
Part II: MAS Receptor / Ang(1-7) / ACE-2:
Introduction
The Mas Story
Basic mechanisms and signaling
Animal models with a genetic alteration of ACE2/MAS
MAS signaling: resolved and unresolved
MAS dimerisation and MAS/AT2 crosstalk
Basic aspects of ACE-2 regulation and function
(Patho)-physiological effects of MAS stimulation
MAS in Myocardial infarction and congestive heart failure
MAS, vascular effects, blood pressure effects
MAS in neuroprotection and -regeneration
MAS and cognitive function
MAS in the kidney
