• The Proteasomal System in Aging and Disease (Hardback) 9780123978639
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The Proteasomal System in Aging and Disease

Written by research experts, this volume of Progress in Molecular Biology and Translational Science focuses on current science surrounding the proteasomal system in aging and disease.

Tilman Grune (Volume editor)

9780123978639, Elsevier Science

Hardback, published 7 August 2012

436 pages
22.9 x 15.1 x 2.8 cm, 0.66 kg

Praise for the series: "Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal

This volume of Progress in Molecular Biology and Translational Science discusses cutting-edge research of proteasomes and proteasome-associated proteins and cellular systems. The volume is split into two sections. The first part discusses the current knowledge of the structure, function, and regulation of the proteasomal system. The second part describes the role of the proteasome in aging and disease.

  1. Structure of the Proteasome

    2. Tobias Jung and Tilman Grune

  2. Structure and Function of the Ubiquitin-Proteasome System: Modulation of Components

    3. Niki Chondrogianni and Efstathios S. Gonos

  3. Immunoproteasomes: Structure, Function, and Antigen Presentation

    4. Deborah A. Ferrington and Dale S. Gregerson

  4. Interactions of the Proteasomal System with Chaperones – Protein Triage and Protein Quality Control

    5. Marc Kästle and Tilman Grune

  5. Proteasome Inhibitors

    6. Boris Cvek

  6. Degradation of Damaged Proteins - The Main Function of the 20S Proteasome

    7. Andrew. M. Pickering and Kelvin. J. A. Davies

  7. Changes of the Proteasomal System During the Aging Process

    8. Martin A. Baraibar and Bertrand Friguet

  8. Proteasome and Cancer

    9. Betul Catalgol

  9. The Ubiquitin Proteasome System and Cardiovascular Disease.

    10. Saul R. Powell, Joerg Herrmann, Amir Lerman, Cam Patterson, Xuejun Wang

  10. Role of the Ubiquitin-Proteasome in Protein Quality Control and Signaling: Implication in the Pathogenesis of Eye Diseases

    11. Fu Shang and Allen Taylor

  11. Proteasome and Neurodegenerative Diseases

Betul Catalgol and Tilman Grune

Subject Areas: Molecular biology [PSD], Biochemistry [PSB], Medical research [MBGR]
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