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The Practice of Medicinal Chemistry
Nicknamed "The Bible" by medicinal chemists shortly after the first edition was published in 1996, this updated text provides a comprehensive overview of the daily issues facing medicinal chemists and pharmaceutical researchers
Camille Georges Wermuth (Edited by), David Aldous (Edited by), Pierre Raboisson (Edited by), Didier Rognan (Edited by)
9780124172050
Hardback, published 17 July 2015
902 pages, 125 illustrations (125 in full color)
27.6 x 21.5 x 4.4 cm, 2.56 kg
"...So that you are a young student of a faculty in the field of pharmacology looking for a formative text, a young researcher at the beginning of his or her experiential work or an expert in the "drug discovery" industry that only wants to deepen theme specifications, most likely in this book you will find what you need." (Google translation) --La Chimica e l’Industria "...provides a diverse, multi-authored yet comprehensive update on the current state of the art in the science of medicinal chemistry…highly recommended for graduate students in the medicinal chemistry and drug discovery sciences." --Drug Development Research Praise for the Third Edition: "The third edition of this book, useful to seasoned medicinal chemists as well as to chemists entering the academic or industrial laboratories, provides a hands-on overview of the drug discovery process. This edition differs from the previous two editions by having been updated to reflect developments in the past 5 years, and it includes 11 new chapters. I found this book to be unique, well organized, and overall a useful addition to the medicinal chemistry literature. Having favorably reviewed the first edition, I still highly recommend this third edition to all chemists who are involved in the drug discovery process." --John L. Neumeyer, Harvard Medical School, Journal of Medicinal Chemistry "...a diverse, multi-authored yet comprehensive update on the current state of the art in the science of medicinal chemistry...highly recommended for graduate students in the medicinal chemistry and drug discovery sciences."--Drug Development Research
The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery.With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development.
Section 1 – General Aspects of Medicinal Chemistry
Section 2 – Lead Compound Discovery Strategies
Section 3 – Primary Exploration of Structure-Activity Relationships
Section 4 – Substituents and Functions: Qualitative and Quantitative Aspects of Structure-Activity Relationships
Section 5 – Spatial Organization, Receptor Mapping and Molecular Modeling
Section 6 – Chemical Modifications Influencing the Pharmacokinetic Properties
Section 7 – Pharmaceutical and Chemical Means to Solubility and Formulation Problems
