The Osteoporosis Primer

The Osteoporosis Primer provides an excellent introduction that relates the clinical presentation of osteoporosis to its molecular biochemical basis, and reviews therapeutic options.

Janet E. Henderson (Edited by), David Goltzman (Edited by)

9780521644464, Cambridge University Press

Paperback, published 24 August 2000

388 pages, 50 b/w illus. 12 tables
24.4 x 17 x 2 cm, 0.62 kg

'This is a concise yet comprehensive synopsis of bone developments and skeletal homeostasis.' Aslib Book Guide

Osteoporosis is one of the leading causes of morbidity and mortality amongst the elderly. The rationale for The Osteoporosis Primer is to provide an introductory text that relates the clinical presentation of osteoporosis to its molecular biochemical basis. The text has been organised into four sections that deal with the molecular/cellular components of bone, the development of peak bone mass, the pathophysiology of aging bone and, finally, how all of these relate to the prevention, diagnosis and treatment of osteoporosis. The international team of authors includes many leading clinicians and scientists who have provided the reader with a concise, yet comprehensive, synopsis of bone development and skeletal homeostasis. This will be an essential introduction for individuals working on osteoporosis including students and doctors considering a career related to metabolic bone disease, physicians in general practice, geriatricians, rheumatologists, and endocrinologists.

Preface Janet E. Henderson and David Goltzman
Part I. Molecular and Cellular Environment of Bone: 1. Endochondral bone formation and development in the axial and appendicular skeletaon A. Robin Poole, Sheila Laverty and Fackson Mwale
2. The role of osteoblasts Jane E. Aubin
3. Osteoclasts: characteristics and regulation of formation and activity Johan Heersche and Morris F. Manolson
4. Bone matrix proteins Marc D. McKee and Jaro Sodek
5. Local regulators of bone turnover Lawrence J. Fraher and Patricia H. Watson
6. The PTH/PTHrP system and calcium homeostasis Geoffrey N. Hendy
7. Vitamin D metabolism Marielle Gascon-Barre
8. Sodium-dependent phosphate transport in kidney, bone and intestine Harriet S. Tenenhouse
Part II. Determinants of Peak Bone Mass: 9. Molecular genetic analysis of growth factor signalling in bone Janet E. Henderson and David Goltzman
10. Genetic determinants of osteoporosis Milan S. Patel, Laurence A. Rubin and David E. C. Cole
11. Non-genetic determinants of peak bone mass Velimir Matkovic and John D. Landoll
12. Bone mineral acquisition during childhood and adolescence: physical exercise as a preventative measure Heather A. McKay and Karim M. Khan
13. Osteoporosis in children Frank Rauch and Francis H. Glorieux
Part III. Pathophysiology of the Aging Skeleton: 14. Consequences of alterations in bone remodeling Karen Prestwood and Lawrence G. Raisz
15. The role of parathyroid hormone and hyperparathyroidism in osteoporosis Pierre D'Amour
16. Senile osteoporosis Patrick M. Doran and Sundeep Khosla
Part IV. Clinical Aspects of Osteoporosis
17. Epidemiology Jaques Brown
18. Biochemical markers of bone turnover David Hanley
19. Radiologic assessment of osteoporosis Jaqueline C. Hodge
20. Bone mineral density measurements Paul D. Miller and Carol Zapalowski
21. Hormone replacement therapy Jonathan D. Adachi and Alexandra Papaioannou
22. Selective estrogen receptor modulators Felicia Cosman and Robert Lindsay
23. Bisphosphonate therapy of osteoporosis Fred Singer and Payam Minoofar
24. The action of fluoride on bone Marc D. Grynpas, D. Chachra and H. Limeback
25. PTH peptides as anabolic agents in bone Anthony B. Hodsman
26. Vitamin D and Vitamin D analogs as therapeutic agents Richard Kremer.

Subject Areas: Endocrinology [MJG]