The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae

Provides a completely new understanding of chronic inflammatory systemic diseases by analyzing the basis of achievements in neuroendocrine immunology

Rainer Straub (Author)

9780128033210

Paperback / softback, published 8 April 2015

390 pages
22.9 x 15.1 x 2.5 cm, 0.76 kg

Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. The uniform response regulates systemic energy and water provision. However, long-term application of this program leads to typical disease sequelae such as fatigue / depressive symptoms, sleep disturbances, anorexia, malnutrition, muscle wasting – cachexia, cachectic obesity, insulin resistance, dyslipidemia, alterations of steroid hormone axes, disturbances of the hypothalamic-pituitary-gonadal axis, elevated sympathetic tone, hypertension, volume expansion, decreased parasympathetic tone, inflammation–related anemia, bone loss, hypercoagulability, circadian rhythms of symptoms, and disease exacerbation by stress .

1. History of immunology research and relevance for chronic inflammatory systemic diseases
2. Pathogenic concepts from psycho-neuroendocrine immunology
3. Energy and volume regulation and chronic inflammatory systemic disease
4. Evolutionary medicine and chronic inflammatory systemic disease
5. Typical disease sequelae in chronic inflammatory systemic diseases
6. Aging related sequalae – inflammaging
7. Continuation and synchronization

Subject Areas: Immunology [MJCM], Diseases & disorders [MJC]