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The Organic Chemistry of Drug Synthesis, 4 Volume Set
Daniel Lednicer (Edited by), D Lednicer (Author), Lester A. Mitscher (Edited by)
9780471531760, Wiley
Hardback, published 25 April 1991
1616 pages
24.4 x 16.1 x 10.3 cm, 2.588 kg
Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.
Preface xi Open-Chain Compounds 1 Peptidomimetic Compounds 2 Antiviral Protease Inhibitors 2 Human Immunodeficiency Virus 2 Human Rhinovirus 9 Miscellaneous Peptidomimetic Compounds 11 References 19 Alicyclic Compounds 21 Monocyclic Compounds 21 Prostaglandins 21 Antiviral Agents 25 Miscellaneous Monocyclic Compounds 29 Polycyclic Compounds: Steroids 31 19-Nor Steroids 31 Corticosteroid Related Compounds 34 Polycyclic Compounds / 38 References 40 Monocyclic Aromatic Compounds 43 Arylcarbonyl Derivatives 43 Biphenyls 47 Compounds Related to Aniline 50 Compounds Related to Arylsulfonic Acids 53 Diarylmethanes 58 Miscellaneous Monocyclic Aromatic Compounds 60 References 67 Carbocyclic Compounds Fused to a Benzene Ring 69 Indenes 69 Naphthalenes 73 Tetrahydronaphthalenes 74 Other benzofused carbocyclic compounds 79 References 81 Five-Membered Heterocycles 83 Compounds with One Heteroatom 83 Compounds with Two Heteroatoms 91 Oxazole and Isoxazoles 91 Imidazoles and a Pyrrazole 94 Thiazoles 99 Triazoles 103 Tetrazoles 109 References 112 Six-Membered Heterocycles 115 Compounds with One Heteroatom 115 Pyridines 115 Reduced Pyridines 117 Miscellaneous 119 Compounds with Two Heteroatoms 121 Pyrimidines 121 Miscellaneous Six-Membered Heterocycles 133 References 136 Five-Membered Heterocycles Fused to One Benzene Ring 139 Compounds with One Heteroatom 139 Benzofurans 139 Indoles 141 Indolones 148 Miscellaneous Compounds with One Heteroatom 153 Five-Membered Rings with Two Heterocyclic Atoms 156 Benzimidazoles 156 Miscellaneous Compounds 158 References 160 Six-Membered Heterocycles Fused to One Benzene Ring 163 Compounds with One Heteroatom 163 Benzopyrans 163 Quinolines and Their Derivatives 167 Quinolone Antibacterial Agents 172 Compounds with Two Heteroatoms 176 Benzoxazines 176 Quinazolines 178 Miscellaneous Benzo-Fused Heterocycles 184 References 186 Bicyclic Fused Heterocycles 189 Compounds with Five-Membered Rings Fused to Six-Membered Rings 189 Compounds with Two Heteroatoms 189 Compounds with Three Heteroatoms 191 Compounds with Four Heteroatoms 195 Compounds with Two Fused Six-Membered Rings 208 Miscellaneous Compounds with Two Fused Heterocyclic Rings: Beta Lactams 213 References 215 Polycyclic Fused Heterocycles 217 Compounds with Three Fused Rings 217 Compounds with Four Fused Rings 228 Compounds with Five or More Fused Rings: Camptothecins 230 References 232 Subject Index 233 Cross Index of Biological Activity 241 Cumulative Index 245
Subject Areas: Chemistry [PN]
