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The Orexin/Hypocretin System
Functional Roles and Therapeutic Potential
Comprehensive coverage of the role this neuropeptide plays in physiology and behavior and its potential as a treatment for related disorders
Jim R. Fadel (Edited by), Joshua A. Burk (Edited by)
9780128137512
Paperback, published 11 January 2019
188 pages
22.9 x 15.1 x 1.3 cm, 0.32 kg
The Orexins/Hypocretins System: Functional Roles and Therapeutic Potential summarizes research on both the physiological functioning of orexins, their impact on homeostatic processes, and related disorders. The book encompasses the effects on appetite, sleep, substance abuse, cognition, and anxiety. Additionally, it examines new therapeutic approaches utilizing orexins, including utilization of orexin receptors for drug development. It is essential reading for neuroscience researchers interested in brain-behavior relationships, as well as psychiatrists, endocrinologists and pharmacologists.
Part 1: Introduction 1. Hypocretins (orexins): 20 years of dissecting arousal circuits 2. Orexins and motivated behaviors Part 2: Orexins and Sleep 3. Orexins and the stabilization of wake/sleep states 4. Orexins and narcolepsy in animal models Part 3: Orexins and Feeding 5. Orexin’s role in motivated behavior for food 6. Orexin drives energy expenditure Part 4. Orexins and Drug Abuse 7. Orexins/hypocretins and addiction 8. Hypocretin 1 receptor regulation of dopaminergic signaling and motivated behavior 9. Orexins and opioid addiction Part 5: Orexins and Cognition 10. Orexins and cognition: neurochemical and anatomical substrates 11. The hypocretin/orexin system and fear learning Part 6: Orexins and Psychological Disorders 12. Orexins and anxiety disorders 13. Orexins as targets for treating brain disorders
Subject Areas: Neurosciences [PSAN], Physiological & neuro-psychology, biopsychology [JMM]
