The Nuclear Overhauser Effect in Structural and Conformational Analysis

David Neuhaus (Author), Michael P. Williamson (Author)

9780471246756, Wiley

Hardback, published 3 May 2000

656 pages
24.2 x 16.2 x 3.4 cm, 0.998 kg

"Describes the theory of the nuclear Overhauser effect, discusses the considerations involved in implementing NOE experiments, and offers examples..." (SciTech Book News, Vol. 24, No. 4, December 2000)

Die theoretischen Grundlagen des Kern-Overhauser-Effekts (NOE) sind weitgehend geklärt. Bewegung gibt es dagegen auf anwendungstechnischem Gebiet, besonders hinsichtlich der Analytik makromolekularer Verbindungen. Der Autor dieses Bandes setzt Grundkenntnisse auf dem Gebiet der NMR-Spektroskopie voraus. Erläutert werden verschiedene Anwendungen der NOE-Spektroskopie auf Probleme der Struktur- und Konformationsaufklärung. (05/00)

THEORY.

Background.

The Steady-State NOE for Two Spins.

The Steady-State NOE in Rigid Multispin Systems.

The Kinetics of the NOE.

The Effects of Exchange and Internal Motion.

Complications from Spin-Spin Coupling.

EXPERIMENTAL.

One-Dimensional Experiments.

The Two-Dimensional NOESY Experiment.

Other Developments.

APPLICATIONS.

Applications of the NOE to Structure Elucidation.

Applications of the NOE to Conformational Analysis.

Calculating Structures of Biopolymers.

Biopolymers.

Appendices.

Index.

Subject Areas: Chemistry [PN]