The Neurobiology of Disease
Contributions from Neuroscience to Clinical Neurology

This volume demonstrates the value of interactions between neurology and the basic sciences that underpin it.

Hugh Bostock (Edited by), P. A. Kirkwood (Edited by), A. H. Pullen (Edited by)

9780521451321, Cambridge University Press

Hardback, published 18 April 1996

464 pages
23.5 x 15.6 x 2.8 cm, 0.85 kg

"...this is a well-written, adequately illustrated, and generally interesting textbook that will be found a useful resource for neuroscientists of all different specialties." Martin Bettag, Neurosurgery Review

This volume demonstrates the value of interactions between neurology and the basic sciences that underpin it. The text considers a range of topics from the points of view of both neurobiologist and clinician and reveals how advances in our understanding are made. The selected topics cover a wide range of levels of organization in the nervous system. For each one, distinguished researchers from around the world make contributions, including general reviews of normal and pathological mechanisms as well as detailed accounts of the basic processes involved. The book's coverage boasts an excellent section on the physiology and pathophysiology of central and peripheral nerve fibres. Also of particular note are the chapters on neuronal plasticity, cell death and axonal regeneration. The book is dedicated to Tom Sears, who at the time of its original publication was retiring as Professor at London's Institute of Neurology (Queen Square).

Part I. Physiology and Pathophysiology of Nerve Fibres: 1. Ion channels in normal and pathophysiological mammalian peripheral myelinated nerve J. M. Ritchie
2. Molecular anatomy of the node of Ranvier: newer concepts S. G. Waxman
3. Delayed rectifier type K+ currents in rabbit and rat axoms and Schwann cells M. Baker
4. Axonal signals for potassium channel expression in Schwann cells T. Konishi
5. Ion channels in human axons G. Reid
6. An in vitro model of diabetic neuropathy: electrophysiological studies P. Grafe
7. Autoimmunity at the neuromuscular junction J. Newsom-Davis
8. The immunopathology and pathophysiology of experimental autoimmune encephalomyelitis M. P. Pender
9. The pathophysiology of human demyelinating neuropathies T. E. Feasby
10. Conduction properties of central demyelinated axons: the generation of symptoms in demyelinating disease K. J. Smith
11. The mechanisms of relapse and remission in multiple sclerosis W. I. McDonald
12. Glial transplantation in the treatment of myelin loss or deficiency J. Rosenbluth
Part II. Pain: 13. Human nociceptors in health and disease J. Ochoa
14. The sensory consequences of inflammation A. Iggo
15. Non-voluntary motor unit activity and myofascial pain syndromes R. H. Westgaard
16. Is there a mechanism for the spinal cord to remember pain? W. D. Willis Jnr
17. The neurophysiological basis of pain relief by acupuncture E. Shen
Part III. Control of Central Nervous System Output: 18. Synaptic transduction in neocortical neurones W. E. Crill
19. Cortical circuits, synchronization and seizures J. G. R. Jefferys
20. Physiologically induced changes of brain temperature and their effect on extracellular field potentials P. Anderson, E. Moser, and V. Jensen
21. Fusimotor patterns of respiratory muscles A. Taylor, and R. Durbarba
22. Cerebral accompaniments and functional significance of the long-latency stretch reflexes in human forearm muscles M. Aminoff, and S. Goodin
23. The cerebellum and proprioceptive control of movement A. Prochazka et al
24. Roles of the lateral nodulus and uvula of the cerebellum in cardiovascular control N. Nishimaru
25. Central actions of curare and gallamine: implications for reticular reflex myoclonus W. Burke
26. The pathophysiology of upper motoneurone disorders H-J. Freund
27. Modulation of hypoglossal motoneurones by thyrotropin releasing hormone and serotonin A. J. Berger et al
28. Serotonin and central respiratory disorders in the newborn G. Hilaire, D. Morin et al
29. Are medullary respiratory neurones multipurpose neurones? L. Grélot et al
30. Reflex control of expiratory motor output in dogs J. R. Romaniuk et al.
31. Abnormal thoracoabdominal movements in patients with chronic lung disease M. Goldman
32. Respiratory rhythm and apnoeas in the newborn B. Duron
33. Cardiorespiratory interactions during apnoea C. P. Seers
34. Impairment of respiratory control in neurological disease R. S. Howard
35. The respiratory muscles in neurological disease G. H. Mills and M. Green
Part IV. Development, Survival, Regeneration and Death: 36. Axonal growth and plasticity in the adult nervous system J. Diamond, and A. Gloster
37. Target dependence of motoneurones I. P. Johnson
38. Rescue of neurones cross-regenerated into foreign targets J. B. Munson, and H. Nishimura
39. Development and repair of neonatal mammalian spinal cord in culture J. G. Nicholls, and Z. Varga
40. Selective neuronal vulnerability in motor neurone diseases with reference to sparing of Onuf's nucleus A. H. Pullen
41. Excitotoxicity in motor neurone diseases C. Krieger.

Subject Areas: Neurology & clinical neurophysiology [MJN]