Freshly Printed - allow 10 days lead
Couldn't load pickup availability
The Natural Anti-Gal Antibody as Foe Turned Friend in Medicine
Provides a comprehensive review of the natural anti-Gal antibody which is the most abundant antibody in humans
Uri Galili (Author)
9780128133620, Elsevier Science
Paperback, published 11 September 2017
304 pages
23.4 x 19 x 2 cm, 0.66 kg
"For anybody who wishes to know the role of these antigens and antibodies in health and disease, the book is a very valuable and readable source. The author is to be congratulated on his lifetime contributions to science, and on collecting these contributions together in this excellent and highly-recommended book." --Xenotransplantation
The Natural Anti-Gal Antibody as Foe Turned Friend in Medicine provides a comprehensive review of the natural anti-Gal antibody, which is the most abundant antibody in humans constituting ~1% of immunoglobulins and the carbohydrate antigen it recognizes, the a-gal epitope. It discusses the discovery of this antigen/antibody system, its evolution in mammals, the pathological effects of this antibody, and its possible use in various therapies in humans. Most significantly, the book discusses microbial and regenerative therapies in which an antibody present in all humans may be harnessed as an in vivo pharmaceutical agent that enables a wide variety of therapies. Some of these therapies are described as experimental studies that are compiled in this book, other already studied therapies in the area of cancer immunotherapy are also included in this book.
SECTION 1: ANTI-GAL BACKGROUND1. Anti-Gal in humans and its antigen the a-gal epitope2. Why do we produce anti-Gal: Evolutionary appearance of anti-Gal in Old World primates3. Anti-Gal comprises most of anti-blood group B antibodies: Landsteiner’s enigma4. Anti-Gal interaction with Trypanosoma, Leishmania and Plasmodium parasites5. Anti-Gal B cells are tolerized by a-gal epitopes in the absence of T cell help SECTION 2: ANTI-GAL AS FOE6. Anti-Gal and other immune barriers in xenotransplantation7. Anti-Gal IgE mediates allergies to red meat8. Anti-Gal and autoimmunity SECTION 3: ANTI-GAL AS FRIEND9. Anti-Gal mediated amplification of viral vaccine efficacy 10. Cancer immunotherapy by anti-Gal mediated in situ conversion of tumors into autologous vaccines11. Anti-Gal as cancer cell destroying antibody and as antibiotics targeted by a-gal bi-functional molecules12. Acceleration of wound and burn healing by anti-Gal/a-gal nanoparticles interaction SECTION 4: FUTURE HYPOTHETICAL DIRECTIONS13. Anti-Gal and anti-non gal antibodies in regeneration of extracellular matrix (ECM) bio-implants in humans 14. Post infarction regeneration of ischemic myocardium by intramyocardial injection of a-gal nanoparticles15. Regeneration of injured spinal cord and peripheral nerves by a-gal nanoparticles16. Inhalation of a-gal/sialic acid liposomes for decreasing influenza virus infection
Subject Areas: Microbiology [non-medical PSG], Life sciences: general issues [PSA], Immunology [MJCM]
