The Mitochondrion in Aging and Disease

This special volume of Progress in Molecular Biology and Translational Science focuses on the mitochondrion in aging and disease.

H.D. Osiewacz (Volume editor)

9780123946256, Elsevier Science

Hardback, published 5 September 2014

290 pages
22.9 x 15.1 x 2.3 cm, 0.52 kg

Mitochondria, the "power plants" of eukaryotic cells, are best known for the generation of adenosine triphosphate (ATP), the universal cellular "energy currency" of the cell, and the synthesis of different essential components. Mitochondrial dysfunction is known to lead to various degenerative disorders, disease, and aging. The Mitochondrion in Aging and Disease works to unravel the processes leading to mitochondrial impairments and of pathways involved in mitochondrial quality control and their impact on health and aging will be addressed.

1. The Mitochondrial Free Radical Theory of Aging
   Gustavo Barja
2. Mitochondrial DNA Mutations in Aging
   Konstantin Khrapko and Doug Turnbull
3. Mathematical Models of Mitochondrial Aging and Dynamics
   Axel Kowald and Edda Klipp
4. Mitochondrial Dynamics in Aging and Disease
   Jürgen Bereiter-Hahn
5. The Retrograde Response – A Conserved Compensatory Reaction to Damage from Within and from Without
   S. Michal Jazwinski
6. Mitochondrial Acetylation and Genetic Models of Parkinson’s Disease
   Georg Auburger, Suzana Gispert and Marina Jendrach
7. Mitochondrial Dysfunction: Cause and Consequence of Alzheimer’s Disease
   Kristina Friedland-Leuner, Carola Stockburger, Isabel Denzer, Gunter P. Eckert and Walter E. Müller
8. Mitochondria in Cancer: Why Mitochondria are a Good Target for Cancer Therapy
   Lan-Feng Dong and Jiri Neuzil
9. Estrogen and Mitochondria Function in Cardiorenal Metabolic Syndrome
   Guanghong Jia, Annayya R. Aroor and  James R. Sowers
10. Advances in Development of Rechargeable Mitochondrial Antioxidants
    Alexander N. Lukashev, Maxim V. Skulachev, Victoria Ostapenko, Alla Yu. Savchenko, V. V. Pavshintsev and Vladimir P. Skulachev
    

Subject Areas: Molecular biology [PSD]