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The Human Microbiota
How Microbial Communities Affect Health and Disease

David N. Fredricks (Author)

9780470479896, Wiley

Hardback, published 23 April 2013

376 pages
26.2 x 18.3 x 2 cm, 0.953 kg

“Overall, this book provides a concise overview of the human microbiota in and on different body sites, a bit too concise for me. It fulfils the intention to discuss many different body sites but in doing so neglects to get to the detailed description of the human microbiota, let alone to give a good overview of their role in health and disease.”  (Beneficial Microbes, 1 March 2014)

“Having said that, I’m sure the book will be of interest to all those studying the effects of micro-organisms on the human body.”  (Microbiology Today, 30 August 2013)

 

The Human Microbiota offers a comprehensive review of all human-associated microbial niches in a single volume, focusing on what modern tools in molecular microbiology are revealing about human microbiota, and how specific microbial communities can be associated with either beneficial effects or diseases. An excellent resource for microbiologists, physicians, infectious disease specialists, and others in the field, the book describes the latest research findings and evaluates the most innovative research approaches and technologies. Perspectives from pioneers in human microbial ecology are provided throughout.

PREFACE vii

CONTRIBUTORS xi

1 THE NIH HUMAN MICROBIOME PROJECT 1
Lita M. Proctor, Shaila Chhibba, Jean McEwen, Jane Peterson, Chris Wellington, Carl Baker, Maria Giovanni, Pamela McInnes, and R. Dwayne Lunsford

2 METHODS FOR CHARACTERIZING MICROBIAL COMMUNITIES ASSOCIATED WITH THE HUMAN BODY 51
Christine Bassis, Vincent Young, and Thomas Schmidt

3 PHYLOARRAYS 75
Eoin L. Brodie and Susan V. Lynch

4 MATHEMATICAL APPROACHES FOR DESCRIBING MICROBIAL POPULATIONS: PRACTICE AND THEORY FOR EXTRAPOLATION OF RICH ENVIRONMENTS 85
Manuel E. Lladser and Rob Knight

5 TENSION AT THE BORDER: HOW HOST GENETICS AND THE ENTERIC MICROBIOTA CONSPIRE TO PROMOTE CROHN’S DISEASE 105
Daniel N. Frank and Ellen Li

6 THE HUMAN AIRWAY MICROBIOME 119
Edith T. Zemanick and J. Kirk Harris

7 MICROBIOTA OF THE MOUTH: A BLESSING OR A CURSE? 135
Angela H. Nobbs, David Dymock, and Howard F. Jenkinson

8 MICROBIOTA OF THE GENITOURINARY TRACT 167
Laura K. Sycuro and David N. Fredricks

9 FUNCTIONAL STRUCTURE OF INTESTINAL MICROBIOTA IN HEALTH AND DISEASE 211

Alexander Swidsinski and Vera Loening-Baucke

10 FROM FLY TO HUMAN: UNDERSTANDING HOW COMMENSAL MICROORGANISMS INFLUENCE HOST IMMUNITY AND HEALTH 255
June L. Round

11 INSIGHTS INTO THE HUMAN MICROBIOME FROM ANIMAL MODELS 273
Bethany A. Rader and Karen Guillemin

12 TO GROW OR NOT TO GROW: ISOLATION AND CULTIVATION PROCEDURES IN THE GENOMIC AGE 289
Karsten Zengler

13 NEW APPROACHES TO CULTIVATION OF HUMAN MICROBIOTA 303
Slava S. Epstein, Maria Sizova, and Amanda Hazen

14 MANIPULATING THE INDIGENOUS MICROBIOTA IN HUMANS: PREBIOTICS, PROBIOTICS, AND SYNBIOTICS 315
George T. Macfarlane and Sandra Macfarlane

INDEX 339

Subject Areas: Biology, life sciences [PS]
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