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The Human Hypothalamus
Neuropsychiatric Disorders

Identifies the neurobiological underpinnings and treatments for hypothalamic related neuropsychiatric, neurodegenerative, periodic and autonomic disorders

Dick F. Swaab (Edited by), Ruud M. Buijs (Edited by), Felix Kreier (Edited by), Paul J. Lucassen (Edited by), Ahmad Salehi (Edited by)

9780128199732, Elsevier Science

Hardback, published 22 February 2022

516 pages
26.2 x 19.2 x 3 cm, 1.36 kg

The Human Hypothalamus: Neuropsychiatric Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer’s, Parkinson’s, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more.

1. Introduction: The human hypothalamus and neuropsychiatric disorders 
SECTION 21  Trauma and iatrogenic disorders
2. Chronic traumatic encephalopathy and the nucleus basalis of Meynert 
SECTION 22  Neurobehavioral disorders
3. Hypothalamic stress systems in mood disorders 
4. Light therapy for mood disorders 
5. Neurobiology of peripartum mental illness 
6. The hypothalamo–pituitary–adrenal axis and the autonomic nervous system in burnout
7. Posterior hypothalamus as a target in the treatment of aggression: From lesioning to deep brain stimulation
8. The implications of hypothalamic abnormalities for schizophrenia 
9. The promiscuity of the oxytocin–vasopressin systems and their involvement in autism
spectrum disorder 
SECTION 23  Epilepsy
10. Gelastic seizures and the hypothalamic hamartoma syndrome: Epileptogenesis beyond the lesion? 
11. The interactions between reproductive hormones and epilepsy 
SECTION 24  Neurodegenerative disorders
12. Alternative splicing in aging and Alzheimer's disease: Highlighting the role of tau and estrogen receptor a isoforms in the hypothalamus 
13. Cholinergic neurodegeneration in Alzheimer disease mouse models 
14. Autonomic disorders in Parkinson disease: Disrupted hypothalamic connectivity as revealed from resting-state functional magnetic resonance imaging
15. Hypothalamic a-synuclein and its relation to autonomic symptoms and neuroendocrine abnormalities in Parkinson disease 
16. Lewy bodies in the olfactory system and the hypothalamus 
17. Hypothalamic pathology in Huntington disease 
18. Endocrine dysfunction in adrenoleukodystrophy 
19. Hypothalamic symptoms of frontotemporal dementia disorders
SECTION 25  Olfactory system
20. The vomeronasal organ: History, development, morphology, and functional neuroanatomy 
21. Pheromone effects on the human hypothalamus in relation to sexual orientation and gender
22. Kallmann syndrome and idiopathic hypogonadotropic hypogonadism: The role of semaphorin signaling on GnRH neurons 
23. Olfaction as an early marker of Parkinson's disease and Alzheimer's disease 
SECTION 26  Autonomic and sleep disorders
24. The hypothalamus and its role in hypertension 
25. The heart is lost without the hypothalamus
26. Sleep disorders and the hypothalamus 
SECTION 27  Addiction and pain
27. Molecular genetics of neurotransmitters and neuropeptides involved in Internet use disorders including first insights on a potential role of hypothalamus’ oxytocin hormone 
28. The neurobiology of cluster headache 
SECTION 28  Critical care and brain-death
29. Endocrine interventions in the intensive care unit 
30. Hypothalamic function in patients diagnosed as brain dead  its practical consequences

Subject Areas: Neurosciences [PSAN], Pathology [MMF], Endocrinology [MJG], Physiology [MFG]

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