The Human Hypothalamus
Middle and Posterior Region

A comprehensive review of the anatomy and neurophysiology of the middle and posterior hypothalamus and its relation to neuropsychiatric, neurological, and homeostatic disorders

Dick F. Swaab (Edited by), Felix Kreier (Edited by), Paul J. Lucassen (Edited by), Ahmad Salehi (Edited by), Ruud M. Buijs (Edited by)

9780128201077, Elsevier Science

Hardback, published 21 September 2021

548 pages
26.2 x 19.2 x 3.2 cm, 1.44 kg

The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the middle and posterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson’s, Alzheimer’s and other neurological disorders relate to the hypothalamus.

1. Introduction: The middle and posterior hypothalamus 
SECTION 6  Supraoptic and paraventricular nucleus more than a neuroendocrine system
2. Vasopressin and oxytocin beyond the pituitary in the human brain
3. Central and peripheral release of oxytocin: Relevance of neuroendocrine and neurotransmitter actions for physiology and behavior 
4. Organization of the neuroendocrine and autonomic hypothalamic paraventricular nucleus 
5. Sex differences of oxytocin and vasopressin in social behaviors 
6. Oxytocin, eating behavior, and metabolism in humans 
7. The supraoptic and paraventricular nuclei in healthy aging and neurodegeneration
8. Perinatal stress and epigenetics 
9. The hypothalamus in anxiety disorders 
10. Congenital isolated central hypothyroidism: Novel mutations and their functional implications 
SECTION 7  Zona incerta
11. The zona incerta system: Involvement in attention and movement
SECTION 8  Ventromedial nucleus and dorsomedial nucleus
12. The role of the dorsomedial and ventromedial hypothalamus in regulating behaviorally coupled and resting autonomic drive 
SECTION 9  Circumventricular organs of the hypothalamus
13. The subfornical organ and organum vasculosum of the lamina terminalis: Critical roles in cardiovascular regulation and the control of fluid balance 
14. Lamina terminalis fenestration: An important neurosurgical corridor 
15. Arcuate nucleus, median eminence, and hypophysial pars tuberalis
16. Tanycytes in the infundibular nucleus and median eminence and their role in the blood–brain barrier 
17. The human hypothalamic kisspeptin system: Functional neuroanatomy and clinical perspectives 
18. Kisspeptin and neurokinin B expression in the human hypothalamus: Relation to reproduction and gender identity 
19. The infundibular peptidergic neurons and glia cells in overeating, obesity, and diabetes
20. Hypothalamus and weight loss in amyotrophic lateral sclerosis 
SECTION 10  Lateral tuberal nucleus
SECTION 11  Lateral hypothalamic area, perifornical area
21. The orexin/hypocretin system in neuropsychiatric disorders: Relation to signs and symptoms 
22. Pleasure, addiction, and hypocretin (orexin) 
SECTION 12  Tuberomamillary complex
23. Histamine receptors, agonists, and antagonists in health and disease 
24. The tuberomamillary nucleus in neuropsychiatric disorders
SECTION 13  Subthalamic nucleus
25. Imaging of the human subthalamic nucleus 
26. Neuropsychiatric effects of subthalamic deep brain stimulation 
27. The subthalamic nucleus and the placebo effect in Parkinson's disease 
SECTION 14   Corpora mamillaria, fornix, and mamillothalamic tract
28. Electrical stimulation of the fornix for the treatment of brain diseases 
29. The contribution of mamillary body damage to Wernicke's encephalopathy and Korsakoff's syndrome

Subject Areas: Neurosciences [PSAN], Neurology & clinical neurophysiology [MJN], Endocrinology [MJG], Medical research [MBGR]