The Human Hypothalamus
Anterior Region

A comprehensive review of the anatomy and neurophysiology of the anterior hypothalamus and its relation to neurologic disorders

Dick F. Swaab (Edited by), Felix Kreier (Edited by), Paul J. Lucassen (Edited by), Ahmad Salehi (Edited by), Ruud M. Buijs (Edited by)

9780128199756, Elsevier Science

Hardback, published 1 September 2021

542 pages
26.2 x 19.2 x 3.1 cm, 1.44 kg

The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the anterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson’s, Alzheimer’s and other neurological disorders relate to the hypothalamus.

SECTION 1  Introduction
1. Introduction: The anterior hypothalamus 
2. History of hypothalamic research: “The spring of primitive existence? 
3. Anatomy and cytoarchitectonics of the human hypothalamus 
4. Morphology and distribution of hypothalamic peptidergic systems 
5. MRI maps, segregation, and white matter connectivity of the human hypothalamus in health 
6. Magnetic resonance imaging of the hypothalamo–pituitary region 
7. Resting-state functional connectivity of the human hypothalamus 
8. Neurogenesis in the adult hypothalamus: A distinct form of structural plasticity involved in metabolic and circadian regulation, with potential relevance for human pathophysiology 
9. Matching of the postmortem hypothalamus from patients and controls 
SECTION 2  The basal forebrain cholinergic system
10. Spatial topography of the basal forebrain cholinergic projections: Organization and vulnerability to degeneration 
11. The diagonal band of Broca in health and disease 
12. Nucleus basalis of Meynert degeneration predicts cognitive impairment in Parkinson's disease 
13. Enlargement of early endosomes and traffic jam in basal forebrain cholinergic neurons in Alzheimer's disease 
14. Gene and cell therapy for the nucleus basalis of Meynert with NGF in Alzheimer's disease
SECTION 3  The circadian system
15. The circadian system: From clocks to physiology 
16. Development of the circadian system and relevance of periodic signals for neonatal development 
17. Disrupted circadian rhythms and mental health 
18. Diurnal and seasonal molecular rhythms in the human brain and their relation to Alzheimer disease 
19. Circadian changes in Alzheimer's disease: Neurobiology, clinical problems, and therapeutic opportunities 
20. The circadian system in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy 
21. Retina and melanopsin neurons 
22. Melatonin and the circadian system: Keys for health with a focus on sleep
23. Melatonin receptors, brain functions, and therapies 
24. Chronotherapy 
25. The use of melatonin to mitigate the adverse metabolic side effects of antipsychotics 
SECTION 4  Bed nucleus of the stria terminalis and the fear circuit
26. Chemoarchitecture of the bed nucleus of the stria terminalis: Neurophenotypic diversity and function 
27. Functional anatomy of the bed nucleus of the stria terminalis–hypothalamus neural circuitry: Implications for valence surveillance, addiction, feeding, and social behaviors 
28. Roles of the bed nucleus of the stria terminalis and amygdala in fear reactions 
SECTION 5  Preoptic area
29. The median preoptic nucleus: A major regulator of fluid, temperature, sleep, and cardiovascular homeostasis
30. The neuroendocrinology of the preoptic area in menopause: Symptoms and therapeutic strategies 
31. The intermediate nucleus in humans: Cytoarchitecture, chemoarchitecture, and relation to sleep, sex, and Alzheimer disease

Subject Areas: Neurosciences [PSAN], Neurology & clinical neurophysiology [MJN], Endocrinology [MJG], Medical research [MBGR]