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The Heart in Rheumatic, Autoimmune and Inflammatory Diseases
Pathophysiology, Clinical Aspects and Therapeutic Approaches
A complete overview of the cardiovascular system in rheumatic, inflammatory, and autoimmune diseases from a pathophysiological and clinical point of view
Udi Nussinovitch (Edited by)
9780128032671
Hardback, published 27 February 2017
766 pages
27.6 x 21.5 x 3.9 cm, 2.24 kg
"I fully recommend The Heart in Rheumatic, Autoimmune and Inflammatory Diseases to clinicians and researchers who aspire to deepen their understanding of these important clinical topics and improve patient care." --Analytical and Bioanalytical Chemistry "...provides a comprehensive and detailed description of the numerous methods in which the cardiovascular system may be involved...a valuable textbook providing useful information to readers with varying degrees of expertise. It is a welcome addition to the library of clinicians and scientist interested in this field." --European Journal of Rheumatology "...this book provides a comprehensive, yet still concise (714 pages), overview on the entire field of inflammatory manifestations in cardiovascular diseases and serves as a reference for optimal management of these conditions."--European Heart Journal
The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives. This book was a result of an extended coordinated collaboration of one-hundred and fifty-four distinguished scientists from thirty-one countries around the globe.
Part I. Immune Medicated Cardiac Injury, Accelerated Atherosclerosis and the Study of Cardiac Involvements in Systemic Diseases 1. Pathophysiology of Autoimmunity and Immune-Mediated Mechanisms in Cardiovascular Diseases 2. Organ-Specific Autoimmune Myocardial Diseases: From Pathogenesis to Diagnosis and Management 3. Autoantibodies Directed Against G-Protein-Coupled Receptors in Cardiovascular Diseases: Basics and Diagnostics 4. Immune-Mediated Accelerated Atherosclerosis 5. A Study of Cardiac Function, Atherosclerosis, and Arrhythmogenicity Part II. Cardiac Manifestations of Inflammatory Arthritis 6. Rheumatoid Arthritis 7. Juvenile Idiopathic Arthritis 8. Spondyloarthritides: Ankylosing Spondylitis, Psoriatic Arthritis, and Reactive Arthritis 9. Polymyalgia Rheumatica Part III. Cardiac Involvement in Autoimmune and Connective Tissue Diseases 10. Systemic Lupus Erythematosus 11. Neonatal Lupus 12. Sjögren’s Syndrome 13. Systemic Sclerosis 14. Dermatomyositis and Polymyositis Part IV. Cardiac Manifestations Crystal-Induced Arthritis 15. Gout Part V. Cardiac Manifestations of Large Vessel Vasculitides 16. Giant Cell Arteritis 17. Takayasu’s Arteritis Part VI. Cardiac Manifestations of Medium Vessel Vasculitides 18. Polyarteritis Nodosa 19. Kawasaki Disease Part VII. Cardiac Manifestations of Small Vessel Vasculitides 20. ANCA-Associated Vasculitis: Microscopic Polyangiitis, Eosinophilic Granulomatosis With Polyangiitis (Churg–Strauss Syndrome) and Granulomatosis With Polyangiitis (Wegener’s Granulomatosis) Part VIII. Cardiac Manifestations of Variable Vessel Vasculitides 21. Behçet’s Disease Part IX. Post-Infectious Autoimmune Cardiac Diseases 22. Rheumatic Fever and Rheumatic Heart Disease 23. Chagas Cardiomyopathy Part X. Autoinflammation 24. Familial Mediterranean Fever Part XI. Therapeutic Approaches: Mechanisms of Action and Cardiac Effects 25. Desirable and Adverse Effects of Antiinflammatory Agents on the Heart 26. The Effects of Immunosuppressive and Cytotoxic Drugs on the Heart 27. Autoantibody-Directed Therapy in Cardiovascular Diseases 28. Cardiac Immunomodulation
Subject Areas: Popular medicine & health [VFD], Allergies [MJCM1], Immunology [MJCM]
