The HDL Handbook
Biological Functions and Clinical Implications

A needed resource covering the basic science, genetics, epidemiology, and treatment of HDL cholesterol as well as potential targets to modify HDL cholesterol, The HDL Handbook: Biological Functions to Clinical Implications will be a needed bridge between laboratory research and clinical practice

Tsugikazu Komoda (Edited by)

9780124078673

Hardback, published 6 November 2013

354 pages
22.9 x 15.1 x 2.5 cm, 0.66 kg

"Editor Komoda's research handbook for physicians and medical scientists addresses in detail the biochemistry and pathophysiology of high-density lipoprotein (HDL) cholesterol. The history of HDL research is summarized in the introduction, including its labeling as "good cholesterol" and recent questions problematizing that label." --ProtoView.com, January 2014

"This is one of the best available sources for a concise yet detailed review of the enormous data on HDL mechanics, genetics, and clinical implications…a very effective and focused presentation for a complex topic…This is an outstanding work. The book is unique in that it not only updates leaders in the field on new advances in HDL research, but it also can jump start beginners in the field." Rating: 4 Stars --Doody.com, February 28, 2014

The HDL Handbook: Biological Functions to Clinical Implications brings laboratory research in HDL from bench to bedside in this needed resource for researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and pathophysiology of cardiovascular diseases. In addition, researchers and clinicians working with an aging population, corporate researchers, post-doctorates; medical students and graduate students will find this publication useful because the scope of coverage includes basic science, genetics, epidemiology, and treatment of HDL cholesterol as well as potential targets to modify HDL cholesterol.

1. Role of phospholipid transfer protein (PLTP) in HDL remodelling and Atherosclerosis
2. The role of CETP in HDL metabolism
3. The physiological role of CETP in HDL molecule metabolism
4. HDL and reverse cholesterol transport: Physiological modulation
5. Serum Paraoxonase PON1 and its interactions with HDL: Relationship between PON1 and oxidative stress
6. Paraoxonase PON1 and its interaction with HDL: Molecular structures of PON1 and HDL
7. Apoliopoprotein A-I mutations
8. The Scavenger Receptor Class B Type I: An HDL Receptor Involved in Lipid Transport and HDL Dependent Signaling
9. HDL and its mimetic peptides: Novel therapeutic strategies for the treatment of inflammatory vascular disease
10. Sterol efflux by ABCA1 and ABCG1
11. Possible roles of oxidized HDL: Structural change of HDL particle by oxidative modification and its contribution to vascular diseases
12. Pre?1-HDL: Conversion to and from spherical ?-migrating HDL in human plasma
13. Determination of circulating native and denaturated HDL concentrations and its clinical implications

Subject Areas: Biochemistry [PSB], Endocrinology [MJG], Haematology [MJF], Cardiovascular medicine [MJD], Metabolism [MFGM]