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The Handbook of Metabolic Phenotyping
A comprehensive description of the growing field of metabolic phenotyping
John C. Lindon (Edited by), Jeremy K. Nicholson (Edited by), Elaine Holmes (Edited by)
9780128122938, Elsevier Science
Paperback, published 5 October 2018
619 pages, 156 illustrations (42 in full color)
22.9 x 15.1 x 3.8 cm, 0.93 kg
The Handbook of Metabolic Phenotyping is the definitive work on the rapidly developing subject of metabolic phenotyping. It explores in detail the wide array of analytical chemistry and statistical modeling techniques used in the field, coupled with surveys of the various application areas in human development, nutrition, disease, therapy, and epidemiology to create a comprehensive exploration of the area of study. It covers recent studies that integrate the various -omics data sets to derive a systems biology view. It also addresses current issues on standardization, assay and statistics validation, and data storage and sharing. Written by experts with many years of practice in the field who pioneered many of the approaches widely used today, The Handbook of Metabolic Phenotyping is a valuable resource for postgrads and research scientists studying and furthering the field of metabolomics.
1. An Overview of Metabolic Phenotyping and Its Role in Systems Biology 2. NMR Spectroscopy Methods in Metabolic Phenotyping 3. The Role of Ultra Performance Liquid Chromatography-Mass Spectrometry in Metabolic Phenotyping 4. GC-MS-Based Metabolic Phenotyping 5. Metabolic Phenotyping Using Capillary Electrophoresis Mass Spectrometry 6. Supercritical Fluid Chromatography for Metabolic Phenotyping: Potential and Applications 7. The iKnife: Development and Clinical Applications of Rapid Evaporative Ionization Mass Spectrometry 8. Univariate Statistical Modeling, Multiple Testing Correction, and Visualization in Metabolome-Wide Association Studies 9. Multivariate Statistical Methods for Metabolic Phenotyping 10. Data-Driven Visualizations in Metabolic Phenotyping 11. Big Data and Databases for Metabolic Phenotyping 12. Progress in Standardization of Metabolic Phenotyping Data 13. Conception, Implementation and Operation of Large-Scale Metabolic Phenotyping Centres: Phenome Centres 14. Applications of Metabolic Phenotyping in Pharmaceutical Research and Development 15. Metabolic Phenotyping in Nutrition Research 16. Metabolic Phenotyping in Clinical Practice 17. Applications of Metabolic Phenotyping in Epidemiology 18. Influence of the Human Gut Microbiome on the Metabolic Phenotype 19. Linking Metabolic Phenotyping and Genomic Information 20. Metabolic Phenotyping: History, Status, and Prospects
Subject Areas: Biochemistry [PSB], Analytical chemistry [PNF]
