The Epigenome and Developmental Origins of Health and Disease

This book reveals how contrasting in utero environmental changes may be leading to epigenetic convergence that result in deleterious phenotypic and physiological effects in offspring, synthesizing the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases.

Cheryl S. Rosenfeld (Edited by)

9780128013830

Paperback, published 23 October 2015

560 pages
23.4 x 19 x 3.5 cm, 1.13 kg

Approx.542 pages

1. The Developmental Origins of Health and Disease (DOHaD) concept: past, present and future.
2. Historical Perspective of Developmental Origins of Health and Disease in Humans
3. DOHaD and the Periconceptional Period, a Critical Window in Time
4. Introduction to Epigenetic Mechanisms: The Probable Common Thread for Various Developmental Origins of Health and Diseases Effects
5. Fetal Neuro-Hormonal Programming and Endocrine Disruption
6. Parental nutrition and developmental origins of health and disease
7. Maternal prenatal stress and the developmental origins of mental health: the role of epigenetics
8. Epigenetics in the Developmental Origin of Cardiovascular Disorders
9. Developmental Effects of Endocrine-Disrupting Chemicals in the Ovary and on Female Fertility
10. Developmental and Epigenetic Origins of Male Reproductive Pathologies
11. Developmental Origins of Childhood Asthma and Allergic Conditions – is there evidence of epigenetic regulation?
12. Immune Disorders, Epigenetics, and the Developmental Origins of Health and Disease
13. Neurobehavioral Disorders and DOHaD
14. Metabolic Disorders and DOHaD
15. The developmental origins of renal dysfunction
16. Cancer and DOHaD- Epigenetic reprogramming as a mediator
17. Epigenetic regulation of gastrointestinal epithelial barrier and developmental origin of health and disease
18. How the Father might Epigenetically Program the Risk for Developmental Origins of Health and Disease Effects in his Offspring
19. Linkage Between in Utero Environmental Changes and Preterm Birth
20. Sexual Dimorphism and DOHaD Through the Lens of Epigenetics
21. Transgenerational Epigenetic Inheritance: Past Exposures, Future Diseases
22. The Placenta and DOHaD
23. The Moral and Legal Relevance of DOHaD Effects for Pregnant Mothers
24. Introduction to Moms in Motion (MIM) Chapter
25. Reversing Harmful DOHaD Effects
26. Informational Resources for Developmental Origins of Health and Disease Research

Subject Areas: Molecular biology [PSD], Developmental biology [PSC], Genetics [non-medical PSAK], Epidemiology & medical statistics [MBNS]