The Enzymes
Protein Methyltransferases

Fuyuhiko Tamanoi (Edited by), Steven G. Clarke (Edited by)

9780121227258, Elsevier Science

Hardback, published 7 July 2006

592 pages, Approx. 100 illustrations (50 in full color)
22.9 x 15.1 x 3.3 cm, 1.04 kg

Protein methylation has recently emerged as one of the most exciting areas of study on posttranslational modification. A large family of protein methyltransferases has been identified and their structural properties have been characterized. These studies have provided novel insights into how methylation regulates a variety of biological functions including DNA and RNA metabolism, protein synthesis and signal transduction. Methylation also plays important roles in aging. This volume is intended to capture these recent developments concerning protein methyltransferases.

Part I: Overview of Protein Methyltransferases
Part II: Modification of Lysine and Arginine Residues in Signal Transduction, Transcription Translation, and Other Functions
Part III: Biological Regulation by Protein Methyl Ester Formation
Part IV: Recognition of Damaged Proteins in Aging by Protein Methyltransferases
Part V: Modification of Proteins by Methylation of Glutamine and Asparagine Residues
Part VI: Inhibition of Metyltransferases by Metabolites

Subject Areas: Animal physiology [PSVD], Enzymology [PSBZ], Biochemistry [PSB], Life sciences: general issues [PSA], Biophysics [PHVN], Physiology [MFG]