The Design of Covalent-Based Inhibitors

Edited by one of the best scientists in the field, this series presents the latest updates in the field

Richard A Ward (Volume editor), Neil Grimster (Volume editor)

9780128216897

Hardback, published 9 July 2021

298 pages
22.9 x 15.2 x 2.3 cm, 0.61 kg

Approx.284 pages

Preface Richard Andrew Ward and Neil Grimster 1. The history of covalent inhibitors Renato A. Bauer 2. Kinetic Mechanisms of Covalent Inhibition Claire Louise McWhirter 3. Covalent Drugs in Development for Immune-Mediated Diseases Leonard Sung 4. Chemistry Perspectives of Reversible Covalent Drugs Jianmin Gao 5. Design of Next-Generation Covalent Inhibitors: Targeting Residues Beyond Cysteine Lyn Jones 6. Boron and Covalent Inhibition Andrew Leach 7. Measuring and predicting warhead and residue reactivity Christopher Rowley 8. Computational Support of Structure-based Targeted Covalent Inhibitor Design Robert Abel 9. Novel approaches to covalent inhibition Nir London 10. The future of covalent inhibition Gyorgy M. Keseru

Subject Areas: Chemistry [PN], Pharmacology [MMG]