The Decade of Autoimmunity

Yehuda Shoenfeld (Edited by)

9780444828248, Elsevier Science

Hardback, published 15 February 1999

431 pages
27.8 x 21 x 2.8 cm, 1.24 kg

"...Well illustrated, some in color. Of interest to endocrinologists and immunologists, both clinical and experimental." --Journal of Endocrine Genetics Vol. 2, No. 3

This book is a direct result of 10 years of the well-known "Autoimmunity Days" in Israel, which are increasingly becoming an international focal point for autoimmunity scientists. Top researchers provide coverage of the most important knowledge generated during the last decade. The volume can therefore be seen almost as a textbook on autoimmunity, projecting from the last decade to the next millennium.A variety of different subjects in autoimmunity, from etiology to pathogenesis, from postulated mechanisms to innovative therapeutic modalities, is handled by noted contributors, while additional authors contribute top papers which significantly enhance a better understanding of autoimmunity.An excellent treatise on the subject, and a worthwhile addition to both clinical and research libraries.

Introduction: The Decade of Autoimunity. 1. The mystery of autoimmune diseases. 2. Innovations in Autoimmunity in the last decade. 3. Thyroiditis and Myocarditis - A tale of two diseases. 4. Autoimmune Thyroid Disease: An expanding spectrum of antibodies to the thyrotropin receptor. 5. The antigens of PBC: Who are they and where do they come from. 6. The search for an animal model for Graves' Disease. 7. Hughes Syndrome: A short history of Antiphopholipid Syndrome (G.R.V. Hughes, M.A. Khamashta). 8. Anticardiolipin antibody, thrombosis and atherosclerosis. 9. B2-glycoprotein I and the Antiphospholipid Syndrome: In vitro and in vivo studies. 10. Clinical associations of antibodies to phospholipids and/or their protein cofactors. 11. Perspectives on Systemic Lupus Erythematosus (SLE) - A model for autoimmunity. 12. Pathogenic aspects of Systemic Lupus Erythematosus. 13. Immunomodulation of experimental antiphospholipid syndrome: Lessons from murine models. 14. Experimental Systemic Lupus Erythematosus: From a pathogenic antibody to immunomodulating proteins. 15. What does the Wolf in Lupus bite? Reflections on the nature of the target antigen in SLE. 16 Brain, Behaviour and Lupus. 17. Sj&ouml
gren's Syndrome: The significance of epithelial cells. 18. SSA/Ro and SSB/La autoantigens, their corresponding antibodies and their clinical relevance. 19. The immunology of diabetes: revolution of concepts over a decade. 20. The pathogenesis and clinical relevance of Heparin-Indiced Autoantibodies. 21. Experimental autoimmune encephalomyelitis induced by various antigens of the central nervous system. Overview and relevance to Multiple Sclerosis. 22. Immunosuppressive and immunomodulating therapeutic approaches for induction of self-tolerance in experimental autoimmune encephalo-myelitis (EAE and CR-EAE) and multiple sclerosis (MS). 23. Development of copolymer 1 (Copaxone®) as a specific drug against multiple sclerosis. 24. Pemphigus, an autoimmune disease of the

Subject Areas: Immunology [MJCM]