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The Colors of Mice
A Model Genetic Network
M. Lynn Lamoreux (Author), Véronique Delmas (Author), Lionel Larue (Author), Dorothy Bennett (Author)
9781405179546, Wiley
Hardback, published 23 April 2010
320 pages
24.9 x 19.3 x 2 cm, 0.907 kg
Serving the needs of pigment cell biologists, cellular physiologists, developmental geneticists, researchers interested in melanoma and more, this new book showcases a blend of new technologies and new insights in the field of pigmantary genetics of mice, with comparative information on other animals. Graduate students can learn here the terminology and scope of the field, and animal fanciers can discover the genetics behind common color variants of mammals. The book is hailed for being written by four of the premier scientists in the field. These authors aim to present the molecular /cellular work in the context of phenotype and the interacting functions of genes that direct the development and function of one biological system. For other researchers, the depth of genetic knowledge on the pigmantary system makes it a valuable model for the study of other systems.
Preface vii Acknowledgments ix Statement regarding the use of pictures x Statement regarding nomenclature xii PART I INTRODUCTION TO THE PIGMENTARY SYSTEM 1 1 Introduction to the Pigmentary System 3 1.1 Introduction 3 1.2 Colors of vertebrate animals 4 1.3 Other pigment cells 12 1.4 The epidermal melanin unit 12 1.5 Mammalian hair 13 1.6 Melanosome biogenesis and translocation 14 1.7 Melanin 15 1.8 Hair growth 15 1.9 Hair growth cycles 17 1.10 Embryonic development of the pigment cell lineage 18 1.11 Pigment cells in culture 18 1.12 Conclusion 19 Appendix: color loci of the mouse 20 PART II THE PIGMENTARY LOCI 49 2 Introduction to Mutant Pigmentary Genes 51 2.1 Defects of normal melanocyte development: white spotting and graying with age 51 2.2 Defects in normal melanosome development: albinism 52 2.3 Transport of melanosomes to other cells: the ‘dilute’ phenotype 53 2.4 Pigment-type switching: from eumelanogenesis to pheomelanogenesis 54 3 White Spotting and Progressive Graying 57 3.1 Definitions and general background 58 3.2 Pigment-cell development: developmental biology 62 3.3 Cellular signaling pathways for melanocytes 71 3.4 Pigment phenotypes and the classical white-spotting genes 88 3.5 The head, heart, ears, and eyes 127 4 ‘Albinism’ and the Failure of Normal Melanosome Development 132 4.1 Background 133 4.2 The melanosomal matrix 140 4.3 The enzymes that catalyze melanogenesis 146 4.4 Membrane proteins that regulate the internal milieu of the melanosome 153 4.5 Protein processing and routing to the maturing melanosome 156 4.6 Melanosome transport 171 5 Pigment-Type Switching 177 5.1 Introduction 178 5.2 Yellow phenotypes 184 5.3 Melanin pigment 189 5.4 Melanogenesis and the eumelanin/pheomelanin switch mechanism 190 5.5 Signaling the switch mechanism at the cellular level 192 5.6 Yellow genes 194 PART III TECHNOLOGY AND RESOURCES 207 6 Novel Mouse Pigmentary Mutants Generated by Genetic Manipulation 209 6.1 Introduction 209 6.2 Mouse transgenesis: generation of genetically engineered mice 210 6.3 Coat-color transgenic mice 219 6.4 The coat-color mutants generated by gene targeting 224 6.5 Influence of the genetic background 229 6.6 Conclusions 230 7 Other Species and Other Resources 232 7.1 Introduction 232 7.2 Resources 233 7.3 Other species 235 References 243 Index 286
Subject Areas: Biology, life sciences [PS]
