The Cholesterol Wars
The Skeptics vs the Preponderance of Evidence

Presents an analytic history of a major controversy in biomedical research and the lessons it offers in dealing with future controversies.

Daniel Steinberg (Edited by)

9780123739797, Elsevier Science

Hardback, published 10 October 2007

248 pages
22.9 x 15.1 x 2.1 cm, 0.58 kg

Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. The Cholesterol Wars chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future.

Thoughts on the Nature of Medical Controversy in General and an Overview of the Cholesterol Controversy in Particular
Animal Models of Atherosclerosis
Early Evidence Linking Hypercholesterolemia to Atherosclerosis and Coronary Heart Disease
Lipoproteins and Metabolism
In Search of a Pathogenesis
Basic Science Foundations
Searching for Drugs that would Lower Blood Cholesterol Safely and Effectively
1984 Coronary Primary Prevention Trial
Statins
A Look at the Future

Subject Areas: Molecular biology [PSD], Lipids [PSBH], Biochemistry [PSB]