The Brain as a Drug Target

Reviews the latest developments in this field

Shafiqur Rahman (Edited by)

9780123855060, Elsevier Science

Hardback, published 22 February 2011

468 pages
22.9 x 15.1 x 2.9 cm, 0.8 kg

PRAISE FOR THE SERIES "Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal

The brain is protected by the blood-brain barrier and this barrier prevents many drugs from entering the brain. This volume discusses various drug delivery and targeting strategies that are being developed to enhance the transport and distribution of drugs into the brain.

1. Monoamine Transporters: Vulnerable and Vital Doorkeepers Zhicheng Lin, Juan J. Canales, Thröstur Björgvinsson, Morgane M. Thomsen, Hong Qu, Qing-Rong Liu, Gonzalo E. Torres, and S. Barak Caine 2. Therapeutic Targets in Alzheimer Disease and Related Tauopathies Christopher P. Corbo and Alejandra del C. Alonso 3. Therapeutic Targets for Neuroprotection and/or Enhancement of Functional Recovery Following Traumatic Brain Injury Matthew L. Kelso and James R. Pauly 4. Insulin, Synaptic Function, and Opportunities for Neuroprotection John G. Mielke and Yu-Tian Wang 5. Molecular Alterations in Glioblastoma: Potential Targets for Immunotherapy Azizul Haque, Naren L. Banik, and Swapan K. Ray 6. Molecular Signaling and Translational Significance of the Corticotropin Releasing Factor System Patrick J. Ronan, and Cliff H. Summers 7. Molecular targets of alcohol action: translational research for pharmacotherapy development and screening Giorgio Gorini, Richard L. Bell, and R. Dayne Mayfield 8. Brain Nicotinic Receptors as Emerging Targets for Drug Addiction: Neurobiology to Translational Research Shafiqur Rahman 9. Glutamatergic Neuroplasticity in Cocaine Addiction Joachim D. Uys and Kathryn J. Reissner 10. Role of the serotonergic system in alcohol dependence: from animal models to clinics Verity R. Johnson, Jason M. Weedman, Youssef Sari

Subject Areas: Neurosciences [PSAN], Pharmacology [MMG], Neurology & clinical neurophysiology [MJN], Pharmaceutical industries [KNDP]