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Telomerases
Chemistry, Biology, and Clinical Applications
Neal F. Lue (Edited by), N Lue (Author), Chantal Autexier (Edited by)
9780470592045, Wiley
Hardback, published 27 July 2012
318 pages
24.1 x 16.3 x 2.3 cm, 0.611 kg
This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research. Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.
Preface vii Contributors ix 1 The Telomerase Complex: An Overview 1 2 Telomerase RNA: Structure, Function, and Molecular Mechanisms 23 3 TERT Structure, Function, and Molecular Mechanisms 53 4 Telomerase Biogenesis: RNA Processing, Trafficking, and Protein Interactions 79 5 Transcriptional Regulation of Human Telomerase 105 6 Telomerase Regulation and Telomere-Length Homeostasis 135 7 Telomere Structure in Telomerase Regulation 157 8 Off-Telomere Functions of Telomerase 201 9 Murine Models of Dysfunctional Telomeres and Telomerase 213 10 Cellular Senescence, Telomerase, and Cancer in Human Cells 243 11 Telomerase, Retrotransposons, and Evolution 265 Index 301
Johanna Mancini and Chantal Autexier
Yehuda Tzfati and Julian J.-L. Chen
Emmanuel Skordalakes and Neal F. Lue
Tara Beattie and Pascal Chartrand
Antonella Farsetti and Yu-Sheng Cong
Joachim Lingner and David Shore
Momchil D. Vodenicharov and Raymund J. Wellinger
Kenkichi Masutomi and William C. Hahn
Yie Liu and Lea Harrington
Phillip G. Smiraldo, Jun Tang, Jerry W. Shay, and Woodring E. Wright
Irina R. Arkhipova
Subject Areas: Chemistry [PN]
