Systemic Drug Delivery Strategies
Volume 2 of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy

Examines recent evolutionary changes in therapy of cancer discussing how to improve on the delivery of immuno-oncology therapy

Mansoor M. Amiji (Edited by), Lara Scheherazade Milane (Edited by)

9780323857819, Elsevier Science

Paperback / softback, published 26 August 2021

588 pages, 170 illustrations (70 in full color)
23.5 x 19 x 3.6 cm, 0.45 kg

Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 examines the challenges of delivering immuno-oncology therapies, focusing specifically on the multiple technologies of affective drug delivery strategies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses methods of targeting tumors, CRISPR technology, and vaccine delivery among many other delivery strategies.

1. Delivery strategies for immune checkpoint blockade inhibitors 2. Delivery strategies for ex vivo and in vivo T-cell reprogramming 3. Delivery strategies for ex vivo and in vivo NK cell reprogramming 4. Delivery strategies for tumor-associated macrophage reprogramming 5. Reprogramming lymphocytes for tumor immunotherapy 6. Targeting tumor-associated neutrophils in immunotherapy 7. Targeting tumor-associated fibroblast in immunotherapy 8. Oncolytic viral particle delivery 9. Extracellular vesicles (exosomes) in tumor immunotherapy 10. Nucleic acid-based delivery and reprogramming for tumor immuno-oncology 11. CRISPR-based gene editing in cancer immunotherapy 12. Delivery strategies for glioma immunotherapy 13. Delivery strategies for STING agonists 14. Delivery strategies for cancer vaccine and immunoadjuvant 15. Targeted delivery and reprogramming myeloid-derived suppressor cells (MDSC) in cancer 16. Delivery of radio-immunotherapy for solid tumors 17. Delivery of photo-immunotherapy for cancer 18. Local immunotherapy of cancer and metastasis 19. Delivery strategies to overcome tumor immunotherapy resistance

Subject Areas: Biotechnology [TCB], Medical toxicology [MMGT], Pharmacology [MMG], Pharmaceutical industries [KNDP]