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Synthetic Biology
Tools and Applications
Thoroughly discusses the challenges and future prospects of designing and fabricating new biological components and systems for pathway, whole cell, and multi-cell applications
Huimin Zhao (Edited by)
9780123944306
Hardback, published 30 May 2013
352 pages
27.6 x 21.5 x 2.5 cm, 1.29 kg
"Synthetic Biology: Tools and Applications. Edited by Huimin Zhao. Academic Press. Amsterdam (The Netherlands) and Boston (Massachusetts): Elsevier. $149.95. xviii 333 p.; ill.; index. ISBN: 978-0-12-394430-6. 2013." --The Quarterly Review of Biology, September 2014 "Chemical, biological, and biochemical engineers describe tools and methodologies developed for engineering biological systems at a wide range of levels, including molecular, pathway, network, whole cell, and multi-cell. They also explore practical applications of synthetic biology, a branch of genetic engineering that incorporates systems biology." --Reference and Research Book News, August 2013 "The proposed book is exclusively focused on synthetic biology. It brings together the thought leaders in this emerging field, giving expert accounts and their opinions of special topics in synthetic biology…. This might be the first dedicated, edited book for synthetic biology." --Dr. Qing Lin, State University of New York at Buffalo, Buffalo, NY, USA
Synthetic Biology provides a framework to examine key enabling components in the emerging area of synthetic biology. Chapters contributed by leaders in the field address tools and methodologies developed for engineering biological systems at many levels, including molecular, pathway, network, whole cell, and multi-cell levels. The book highlights exciting practical applications of synthetic biology such as microbial production of biofuels and drugs, artificial cells, synthetic viruses, and artificial photosynthesis. The roles of computers and computational design are discussed, as well as future prospects in the field, including cell-free synthetic biology and engineering synthetic ecosystems.Synthetic biology is the design and construction of new biological entities, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. It builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components that can be modeled, understood, and tuned to meet specific performance criteria and the assembly of these smaller parts and devices into larger integrated systems that solve specific biotechnology problems.
IntroductionSection I. Synthesis and engineering tools in synthetic biology1. DNA synthesis 2. Protein engineering 3. Pathway engineering 4. Biological standardization Section II. Computational and theoretical tools in synthetic biology5. Biocomplexity issues in synthetic biology 6. Computational protein design7. Computer-Aided Design in Synthetic Biology8. Computational tools for strain design Sections III. Applications in synthetic biology9. Pathway/network level: design and applications of therapeutic genetic circuits 10. Pathway/network level: production of drugs 11. Pathway/network level: synthesis of new fuels 12. Organism level: genome assembly 13. Multi-cell level: synthetic prey-predator system Section IV. Future prospects14. Design of artificial cells15. Cell-free synthetic biology 16. Artificial photosynthesis 17. Engineering synthetic ecosystems
