Surface Modification of Biomaterials
Methods Analysis and Applications

Rachel Williams (Edited by)

9780081014691, Elsevier Science

Paperback / softback, published 19 August 2016

432 pages
23.3 x 15.6 x 2.7 cm, 0.61 kg

The surface modification of biomaterials plays a significant role in determining the outcome of biological-material interactions. With the appropriate modification a material’s surface can be tailored to improve biocompatibility, adhesion and cell interactions. Consequently surface modification is vital in the development and design of new biomaterials and medical devices. Surface modification of biomaterials reviews both established surface modifications and those still in the early stages of research and discusses how they can be used to optimise biological interactions and enhance clinical performance.

Part one begins with chapters looking at various types and techniques of surface modification including plasma polymerisation, covalent binding of poly (ethylene glycol) (PEG), heparinisation, peptide functionalisation and calcium phosphate deposition before going on to examine metal surface oxidation and biomaterial surface topography to control cellular response with particular reference to technologies, cell behaviour and biomedical applications. Part two studies the analytical techniques and applications of surface modification with chapters on analysing biomaterial surface chemistry, surface structure, morphology and topography before moving onto discuss modifying biomaterial surfaces to optimise interactions with blood, control infection, optimise interactions with soft tissues, repair and regenerate nerve cells, control stem cell growth and differentiation and to optimise interactions with bone.

The distinguished editor and international team of contributors to Surface modification of biomaterials have produced a unique overview and detailed chapters on a range of surface modification techniques which will provide an excellent resource for biomaterials researchers and scientists and engineers concerned with improving the properties of biomaterials. It will also be beneficial for academics researching surface modification.

Part 1 Surface modification techniques: Surface modification of biomaterials by plasma polymerisation
Surface modification of biomaterials by covalent binding of poly(ethylene glycol) (PEG)
Surface modification of biomaterials by heparinisation to improve blood compatibility
Surface modification of biomaterials by peptide functionalisation
Metal surface oxidation and surface interactions
Surface modification of biomaterials by calcium phosphate deposition
Biomaterial surface topography to control cellular response: Technologies, cell behaviour and biomedical applications. Part 2 Analytical techniques and applications: Techniques for analysing biomaterial surface chemistry
Techniques for analysing biomaterial surface structure, morphology and topography
Modifying biomaterial surfaces to optimise interactions with blood
Modifying biomaterials surfaces with bioactives to control infection
Modifying biomaterial surfaces to optimise interactions with soft tissues
Modifying biomaterial surfaces for the repair and regeneration of nerve cells
Modifying biomaterial surfaces to control stem cell growth and differentiation
Modifying biomaterial surfaces to optimise interactions with bone.

Subject Areas: Materials science [TGM], Biotechnology [TCB], Biomedical engineering [MQW], Medical equipment & techniques [MBG]