Studies in Natural Products Chemistry
Stereoselective Synthesis

Atta-ur Rahman (Edited by)

9780444893666, Elsevier Science

Hardback, published 3 March 1993

548 pages
22.9 x 15.1 x 3.2 cm, 1.14 kg

Studies in Natural Products Chemistry Volume 12: Stereoselective Synthesis (Part H) reviews the stereoselective synthetic and mechanistic chemistry of bicyclomycin. It discusses chemical studies of the taxane diterpenes; the synthetic methodology for 2-amino alcohols of biological interest; and the synthesis and structure of hydroxylated indolizidines. Some of the topics covered in the book are the synthetic routes to the oxahydrindene subunit of the avermectin-milbemycin family of antiparasitic agents; isolation, structure elucidation, biosynthesis, and biological activity of the avermectins; two-stage coupling process of macrolide antibiotics synthesis; and synthesis of the rifamycin S ansa-chain compound. The complete synthesis of erythromycin A is also covered. The role of isocyanides in the synthesis of beta lactam antibiotics and the characteristics of the beta lactam antibiotics are discussed. The development of an A-Ring annulation strategy for taxane synthesis is also presented. A chapter is devoted to the advances in the synthesis of tumor-promoting diterpenes. The book can provide useful information to chemists, biologists, students, and researchers.

Preface

Foreword

Contributors

Synthetic Routes to the Oxahydrindene Subunit of the Avermectinmilbemycin Family of Antiparasitic Agents: A Review

A New Tandem Process and its Application to the Syntheses of Macrolide Antibiotics

Stereoselective Synthetic and Mechanistic Chemistry of Bicyclomycin

The Role of Isocyanides in the Synthesis of ß-Lactam Antibiotics and Related Compounds

Synthesis of the 1ß-Methylcarbapenem Key Intermediates

Chemical Studies of the Taxane Diterpenes

Recent Advances in the Synthesis of Tumor-Promoting Diterpenes

Hydroxylated Indolizidines and Their Synthesis

A Survey of Indolo [2,3-a] Carbazole Alkaloids and Related Natural Products

Synthetic Methodology For 2-Amino Alcohols of Biological Interest

Stereoselective Synthesis of Natural Products Via Cationic and Radical Intermediates

Subject Index

Subject Areas: Organic chemistry [PNN], Inorganic chemistry [PNK]